Rabbit Polyclonal SOCS6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Fusion protein corresponding to aa 350-500 of SOCS6, fused to SOCS6.
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Publications
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- JCI insight 8:2023Reprogramming of PD-1+ M2-like tumor-associated macrophages with anti-PD-L1 and lenalidomide in cutaneous T cell lymphoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhen Han,Xiwei Wu,Hanjun Qin,Yate-Ching Yuan,Daniel Schmolze,Chingyu Su,Jasmine Zain,Lilach Moyal,Emmilia Hodak,James F Sanchez,Peter P Lee,Mingye Feng,Steven T Rosen,Christiane QuerfeldPubMed 37427589
- Kidney & blood pressure research 47:247-2552022MicroRNA-494-3p Exacerbates Renal Epithelial Cell Dysfunction by Targeting SOCS6 under High Glucose Treatment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXianjun Xue,Minjie Liu,Yulu Wang,Yanlei Yang,Zhiping Li,Ruifang Shi,Yueting MiaoPubMed 35038704
- Diagnostic pathology 16:1132021Down-regulation of SOCS6: an unfavorable prognostic factor for gastrointestinal stromal tumor proven by survival analysis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJun Ouyang,Tailai An,Yan Wang,Xiaofang Lu,Yawei Zhang,Xiaokun Wang,Xinhua Zhang,Changhua ZhangPubMed 34895274
- Cancer cell international 21:1652021SOCS6 promotes radiosensitivity and decreases cancer cell stemness in esophageal squamous cell carcinoma by regulating c-Kit ubiquitylation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXuanzi Sun,Yuchen Sun,Jing Li,Xu Zhao,Xiaobo Shi,Tuotuo Gong,Shupei Pan,Zhongqiang Zheng,Xiaozhi ZhangPubMed 33712005
- Inflammation 44:1607-16192021Circ_0085289 Alleviates the Progression of Periodontitis by Regulating let-7f-5p/SOCS6 Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWenwen Du,Li Wang,Zhen Liao,Juan WangPubMed 33710445
- Genes & diseases 9:697-7042020Liver-specific Mettl3 ablation delays liver regeneration in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJiaxiang Meng,Zhicong Zhao,Zhifeng Xi,Qiang XiaPubMed 35782970
- Bioscience reports 40:2020Regulation of the miR-19b-mediated SOCS6-JAK2/STAT3 pathway by lncRNA MEG3 is involved in high glucose-induced apoptosis in hRMECs.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFan Xiao,Lan Li,Jing-Song Fu,Yu-Xiang Hu,Rong LuoPubMed 32519748
- Oxidative medicine and cellular longevity 2020:62639212020miR-155-5p Implicates in the Pathogenesis of Renal Fibrosis via Targeting SOCS1 and SOCS6.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWanfen Zhang et. al.PubMed 32587662
- Cell death & disease 10:1122019miR-1260b, mediated by YY1, activates KIT signaling by targeting SOCS6 to regulate cell proliferation and apoptosis in NSCLC.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYang Xia et. al.PubMed 30737371
- Cell death & disease 9:10422018Long noncoding RNA neuroblastoma-associated transcript 1 gene inhibits malignant cellular phenotypes of bladder cancer through miR-21/SOCS6 axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhongyuan Liu et. al.PubMed 30310053
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Fusion protein corresponding to aa 350-500 of SOCS6, fused to SOCS6. The exact immunogen used to generate this antibody is proprietary information. Database link O14544
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/200.00000 - 1/1000.00000 | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes - |
Target data
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
Alternative names
CIS4, SOCS4, SOCS6, Suppressor of cytokine signaling 6, SOCS-6, Cytokine-inducible SH2 protein 4, Suppressor of cytokine signaling 4, CIS-4, SOCS-4
Recommended products
Rabbit Polyclonal SOCS6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Fusion protein corresponding to aa 350-500 of SOCS6, fused to SOCS6.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Fusion protein corresponding to aa 350-500 of SOCS6, fused to SOCS6. The exact immunogen used to generate this antibody is proprietary information. Database link O14544
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
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2 product images
Western blot - Anti-SOCS6 antibody (ab197335)
All lanes: SOCS6 Antibody at 1/300 dilution
All lanes: Human placenta tissue lysate at 40 µg
SecondaryAll lanes: Goat anti rabbit IgG at 1/5000 dilution
Predicted band size: 60 kDa
Exposure time: 3min
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS6 antibody (ab197335)
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling SOCS6 with ab197335 at 1/50 dilution.
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