AB197335

Anti-SOCS6 antibody

Name: Anti-SOCS6 antibody (ab197335) | Abcam
Brand: Abcam Limited
SKU: AB197335

Be the first to review this product! Submit a review

(12 Publications)

Rabbit Polyclonal SOCS6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Fusion protein corresponding to aa 350-500 of SOCS6, fused to SOCS6.

View Alternative Names

CIS4, SOCS4, SOCS6, Suppressor of cytokine signaling 6, SOCS-6, Cytokine-inducible SH2 protein 4, Suppressor of cytokine signaling 4, CIS-4, SOCS-4

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS6 antibody (AB197335)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS6 antibody (AB197335)

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling SOCS6 with ab197335 at 1/50 dilution.

Unknown

Western blot - Anti-SOCS6 antibody (AB197335)

All lanes:

SOCS6 Antibody at 1/300 dilution

All lanes:

Human placenta tissue lysate at 40 µg

Secondary

All lanes:

Goat anti rabbit IgG at 1/5000 dilution

Predicted band size: 60 kDa

false

Exposure time: 3min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Fusion protein corresponding to aa 350-500 of SOCS6, fused to SOCS6. The exact immunogen used to generate this antibody is proprietary information.

O14544

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" } } }

style

left-column

Product details

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.

See full target information SOCS6

style

left-column

Publications (12)

Recent publications for all applications. Explore the full list and refine your search

JCI insight 8: PubMed37427589

2023

Reprogramming of PD-1+ M2-like tumor-associated macrophages with anti-PD-L1 and lenalidomide in cutaneous T cell lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Han,Xiwei Wu,Hanjun Qin,Yate-Ching Yuan,Daniel Schmolze,Chingyu Su,Jasmine Zain,Lilach Moyal,Emmilia Hodak,James F Sanchez,Peter P Lee,Mingye Feng,Steven T Rosen,Christiane Querfeld

Innate immunity 28:174-184 PubMed35678490

2022

Circ_0062491 alleviates LPS-induced apoptosis and inflammation in periodontitis by regulating miR-498/SOCS6 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Lie Wang,Yanli Li,Feifei Hong,Haiyan Ning

Kidney & blood pressure research 47:247-255 PubMed35038704

2022

MicroRNA-494-3p Exacerbates Renal Epithelial Cell Dysfunction by Targeting SOCS6 under High Glucose Treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Xianjun Xue,Minjie Liu,Yulu Wang,Yanlei Yang,Zhiping Li,Ruifang Shi,Yueting Miao

Diagnostic pathology 16:113 PubMed34895274

2021

Down-regulation of SOCS6: an unfavorable prognostic factor for gastrointestinal stromal tumor proven by survival analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Ouyang,Tailai An,Yan Wang,Xiaofang Lu,Yawei Zhang,Xiaokun Wang,Xinhua Zhang,Changhua Zhang

Cancer cell international 21:165 PubMed33712005

2021

SOCS6 promotes radiosensitivity and decreases cancer cell stemness in esophageal squamous cell carcinoma by regulating c-Kit ubiquitylation.

Applications

Unspecified application

Species

Unspecified reactive species

Xuanzi Sun,Yuchen Sun,Jing Li,Xu Zhao,Xiaobo Shi,Tuotuo Gong,Shupei Pan,Zhongqiang Zheng,Xiaozhi Zhang

Inflammation 44:1607-1619 PubMed33710445

2021

Circ_0085289 Alleviates the Progression of Periodontitis by Regulating let-7f-5p/SOCS6 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wenwen Du,Li Wang,Zhen Liao,Juan Wang

Genes & diseases 9:697-704 PubMed35782970

2020

Liver-specific Mettl3 ablation delays liver regeneration in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jiaxiang Meng,Zhicong Zhao,Zhifeng Xi,Qiang Xia

Bioscience reports 40: PubMed32519748

2020

Regulation of the miR-19b-mediated SOCS6-JAK2/STAT3 pathway by lncRNA MEG3 is involved in high glucose-induced apoptosis in hRMECs.

Applications

Unspecified application

Species

Unspecified reactive species

Fan Xiao,Lan Li,Jing-Song Fu,Yu-Xiang Hu,Rong Luo

Oxidative medicine and cellular longevity 2020:6263921 PubMed32587662

2020

miR-155-5p Implicates in the Pathogenesis of Renal Fibrosis via Targeting SOCS1 and SOCS6.

Applications

Unspecified application

Species

Unspecified reactive species

Wanfen Zhang,Xiaoping Li,Yushang Tang,Cheng Chen,Ran Jing,Tongqiang Liu

Cell death & disease 10:112 PubMed30737371

2019

miR-1260b, mediated by YY1, activates KIT signaling by targeting SOCS6 to regulate cell proliferation and apoptosis in NSCLC.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Xia,Ke Wei,Feng-Ming Yang,Liu-Qing Hu,Chun-Feng Pan,Xiang-Long Pan,Wei-Bing Wu,Jun Wang,Wei Wen,Zhi-Cheng He,Jing Xu,Xin-Feng Xu,Quan Zhu,Liang Chen

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SOCS6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS6 antibody (AB197335)

Western blot - Anti-SOCS6 antibody (AB197335)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (12)

Product promise