JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB2048

Anti-SODD antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal SODD antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human BAG4 aa 1-50.

View Alternative Names

SODD, BAG4, BAG family molecular chaperone regulator 4, BAG-4, Bcl-2-associated athanogene 4, Silencer of death domains

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-SODD antibody (AB2048)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SODD antibody (AB2048)

ab2048 at 5μg/ml staining SODD in Hela cells by ICC/IF

Immunocytochemistry/ Immunofluorescence - Anti-SODD antibody (AB2048)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SODD antibody (AB2048)

Immunofluorescence of SODD in Hela cells using ab2048 at 20 ug/ml.

Western blot - Anti-SODD antibody (AB2048)
  • WB

Unknown

Western blot - Anti-SODD antibody (AB2048)

All lanes:

Western blot - Anti-SODD antibody (ab2048) at 1/500 dilution

Lane 1:

HeLa whole cell lysate with absence of blocking peptide

Lane 2:

THP-1 whole cell lysate with absence of blocking peptide

Lane 3:

HeLa whole cell lysate with SODD peptide (<a href='/en-us/products/unavailable/sodd-peptide-ab8382'>ab8382</a>)

Lane 4:

THP-1 whole cell lysate with SODD peptide (<a href='/en-us/products/unavailable/sodd-peptide-ab8382'>ab8382</a>)

Predicted band size: 50 kDa

Observed band size: 60 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human BAG4 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

O95429

style
left-column

Alternative Products

Primary Antibodies

AB108988

Anti-SODD antibody [EPR3596]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-SODD antibody [EPR3596] (AB108988)

  • 0
  • 0
Primary Antibodies

AB134051

Anti-SODD antibody [EPR3597]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SODD antibody [EPR3597] (AB134051)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB22048

Anti-TLR4 antibody [76B357.1]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLR4 antibody [76B357.1] (AB22048)

  • 4
  • 29
Primary Antibodies

AB32360

Anti-NFkB p105 / p50 antibody [E381]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NFkB p105 / p50 antibody [E381] (AB32360)

  • 4
  • 21
Primary Antibodies

AB33915

Anti-TRAF6 antibody [EP591Y]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAF6 antibody [EP591Y] (AB33915)

  • 4
  • 9
Primary Antibodies

AB134064

Anti-STUB1/CHIP antibody [EPR4447]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-STUB1/CHIP antibody [EPR4447] (AB134064)

  • 4
  • 9
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "5 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
style
left-column

Product details

Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for SODDs. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Ion exchange chromatography DEAE-C
Purification notes
SODD Antibody is Antibody is DEAE purified.
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.
See full target information BAG4
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 16:3753-3760 PubMed29067445

2017

Bcl‑2 associated athanogene 4 promotes proliferation, migration and invasion of gastric cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Lizhi Yi,Zhenbing Lv,Jianmei Wang,Xianfei Zhong

The Journal of biological chemistry 288:6980-90 PubMed23341456

2013

The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737.

Applications

WB

Species

Human

Mariana Boiani,Cristina Daniel,Xueyuan Liu,Michael D Hogarty,Lawrence J Marnett
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com