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AB90630

Anti-Sodium/Hydrogen Exchanger 3/NHE-3 antibody

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(1 Publication)

Rabbit Polyclonal Sodium/Hydrogen Exchanger 3/NHE-3 antibody. Suitable for WB, IHC-Fr and reacts with Human samples. Cited in 1 publication.

View Alternative Names

NHE3, SLC9A3, Sodium/hydrogen exchanger 3, Na(+)/H(+) exchanger 3, Solute carrier family 9 member 3, NHE-3

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-Fr, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Sodium/Hydrogen Exchanger 3 (NHE-3) also known as the Na/H Exchanger is an important protein responsible for sodium ion transport across cell membranes mainly in exchange for protons (H+ ions). Its molecular mass is approximately 85 kDa. NHE-3 is extensively expressed in epithelial cells particularly in the renal proximal tubules and the small intestine where it plays an essential role in fluid and electrolyte balance.
Biological function summary

The NHE-3 transporter facilitates the reabsorption of sodium ions contributing to cellular pH regulation and volume control. It operates as part of a larger multiprotein complex involving various regulatory proteins that fine-tune its activity. The exchanger activity is critical for maintaining homeostasis and proper cellular function influencing processes like nutrient absorption and acid-base balance in different tissues.

Pathways

The NHE-3 transporter plays significant roles in fluid reabsorption and bicarbonate reabsorption pathways. It functions in concert with other transporters and channels such as the Na-K ATPase pump which is key to maintaining sodium and potassium gradients. These pathways highlight the exchanger's contributions to renal and digestive systems emphasizing its interaction with proteins such as carbonic anhydrase within these processes.

Issues with NHE-3 function link to hypertension and chronic kidney disease. Malfunction or dysregulation of this Na/H exchanger can disrupt sodium balance and blood pressure regulation leading to these conditions. Changes in NHE-3 activity also connect to pathologies involving other proteins like Angiotensin II which can influence its expression and activity within the renal system further impacting disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plasma membrane Na(+)/H(+) antiporter (PubMed : 18829453, PubMed : 26358773, PubMed : 35613257). Exchanges intracellular H(+) ions for extracellular Na(+) in 1 : 1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed : 24622516, PubMed : 26358773).
See full target information SLC9A3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Archives of oral biology 90:19-26 PubMed29524788

2018

Functional and molecular characterization of transmembrane intracellular pH regulators in human dental pulp stem cells.

Applications

WB

Species

Unspecified reactive species

Gunng-Shinng Chen,Shiao-Pieng Lee,Shu-Fu Huang,Shih-Chi Chao,Chung-Yi Chang,Gwo-Jang Wu,Chung-Hsing Li,Shih-Hurng Loh
View all publications
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