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AB9979

Anti-Soluble TNF Receptor I antibody

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(2 Publications)

Rabbit Polyclonal TNF Receptor I antibody. Suitable for ELISA, WB, sELISA and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TNFRSF1A.

View Alternative Names

CD120a, TNFAR, TNFR1, TNFRSF1A, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I, p55, p60, TNF-R1, TNF-RI, TNFR-I

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Light chain type

unknown

Carrier free

No

Reacts with

Human

Applications

sELISA, WB, ELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TNFRSF1A.

P19438

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Reactivity data

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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with water at 200µL
Purification technique
Affinity purification Immunogen
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Soluble TNF Receptor I also known as sTNFR1 or sTNFR55 functions as a decoy receptor for tumor necrosis factor (TNF). It binds to members of the TNF ligand family particularly TNF-alpha preventing them from interacting with cell-bound receptors. This receptor has a molecular weight of approximately 30 kDa. You will find sTNFR1 expressed in various tissues including lung liver and kidney. sTNFR1 circulates in blood where it plays a role in modulating immune responses.
Biological function summary

Soluble TNF Receptor I is involved in regulating inflammation. It sequesters TNF to control its bioavailability and impede its pro-inflammatory effects. sTNFR1 is part of a larger signaling complex which also includes other TNF receptors and ligands within the TNF receptor superfamily. This ability to regulate TNF activity suggests its important role in maintaining immune system balance and preventing excessive inflammation.

Pathways

Soluble TNF Receptor I modulates key inflammatory pathways including the NF-kB and MAPK pathways. These pathways are critical in the cellular response to stress apoptosis and survival. By binding TNF-alpha sTNFR1 interferes with TNF-alpha's interaction with TNFR1 and TNFR2 cell receptors which are vital in signaling through these pathways. TNFR1 particularly mediates a range of cellular responses including apoptosis and survival by influencing downstream kinases and transcription factors.

Soluble TNF Receptor I has associations with inflammatory and autoimmune conditions. In conditions like rheumatoid arthritis sTNFR1 counteracts the excessive activity of TNF an important mediator of inflammation. It is also connected to cancer where dysregulated TNF signaling may contribute to tumor progression. Through these conditions sTNFR1 directly interacts with TNF-alpha and TNFRs drawing a connection between TNF signaling and disease pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
See full target information TNFRSF1A
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in microbiology 14:1197092 PubMed37389334

2023

Altered intestinal microbiota in children with bronchiolitis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Bin Wu,Jian Wang,Yuan Tang,Jing Jiang,Xue-Mei Li

BMC immunology 18:39 PubMed28747172

2017

Characteristics of the specific humoral response in patients with advanced solid tumors after active immunotherapy with a VEGF vaccine, at different antigen doses and using two distinct adjuvants.

Applications

Unspecified application

Species

Unspecified reactive species

Javier Sánchez Ramírez,Yanelys Morera Díaz,Mónica Bequet-Romero,Francisco Hernández-Bernal,Katty-Hind Selman-Housein Bernal,Ana de la Torre Santos,Eduardo Rafael Santiesteban Álvarez,Yenima Martín Bauta,Cimara H Bermúdez Badell,Josué de la Torre Pupo,Jorge V Gavilondo,Marta Ayala Avila
View all publications
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