Mouse Polyclonal Solute carrier family 22 member 18 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SLC22A18.
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Publications
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- Pharmaceutical research 36:392019Knockdown of Orphan Transporter SLC22A18 Impairs Lipid Metabolism and Increases Invasiveness of HepG2 Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShingo Ito,Gentaro Honda,Yu Fujino,Seiryo Ogata,Mio Hirayama-Kurogi,Sumio OhtsukiPubMed 30635741
- Journal of pharmaceutical sciences 107:3163-31702018Involvement of an Orphan Transporter, SLC22A18, in Cell Growth and Drug Resistance of Human Breast Cancer MCF7 Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShingo Ito et. al.PubMed 30145211
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 100% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human SLC22A18. Database link Q96BI1
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1 µg/mL | Notes - |
Target data
Function
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.
Alternative names
BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, SLC22A1L, TSSC5, SLC22A18, Solute carrier family 22 member 18, Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein, Efflux transporter-like protein, Imprinted multi-membrane-spanning polyspecific transporter-related protein 1, Organic cation transporter-like protein 2, Solute carrier family 22 member 1-like, Tumor-suppressing STF cDNA 5 protein, Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein, p45-Beckwith-Wiedemann region 1 A, ORCTL-2, p45-BWR1A
Recommended products
Mouse Polyclonal Solute carrier family 22 member 18 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SLC22A18.
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 100% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human SLC22A18. Database link Q96BI1
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Solute carrier family 22 member 18 (SLC22A18) also known as BWR1A is a transporter protein that plays a role in moving organic cations across cell membranes. It is a member of the solute carrier family 22 which includes several transporters that facilitate the movement of various molecules. The molecular mass of SLC22A18 is approximately 61 kDa. It is mostly expressed in tissues such as the kidney placenta and liver where it contributes to the regulation of extracellular and intracellular concentrations of organic ions.
- Biological function summary
SLC22A18 functions in the uptake and extrusion of organic cations impacting cellular homeostasis and metabolism. It is not part of a complex but instead works individually within the cells. This protein helps in maintaining the balance of metabolites and xenobiotics substances foreign to an organism's body influencing processes including detoxification and metabolic regulation.
- Pathways
SLC22A18 participates in the organic cation transport pathway and the xenobiotic metabolism pathway. It is related to proteins in these pathways such as other solute carriers which together maintain the transport of various cations and metabolites across cellular membranes. This action assists various cells in handling foreign substances by regulating their uptake and excretion to adapt to various internal and external environments.
- Associated diseases and disorders
SLC22A18 has associations with cancer and metabolic syndrome. Changes in its expression or function can affect cellular detoxification abilities which may lead to the development of certain cancers due to an accumulation of harmful compounds. In metabolic syndrome altered SLC22A18 function can disturb normal metabolism. This protein interacts with other solute carriers and transporters to influence disease progression through its key role in transporting critical molecules within the body.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-Solute carrier family 22 member 18 antibody (ab168960)
All lanes: Western blot - Anti-Solute carrier family 22 member 18 antibody (ab168960) at 1 µg/mL
Lane 1: Solute carrier family 22 member 18 transfected 293T cell lysate at 15 µL
Lane 2: Non-transfected 293T cell lysate at 15 µL
Developed using the ECL technique.
Predicted band size: 45 kDa
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