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AB168960

Anti-Solute carrier family 22 member 18 antibody

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(2 Publications)

Mouse Polyclonal Solute carrier family 22 member 18 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SLC22A18.

View Alternative Names

BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, SLC22A18, SLC22A1L, TSSC5, Solute carrier family 67 member A1, Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein, Efflux transporter-like protein, Imprinted multi-membrane-spanning polyspecific transporter-related protein 1, Organic cation transporter-like protein 2, Solute carrier family 22 member 1-like, Solute carrier family 22 member 18, Tumor-suppressing STF cDNA 5 protein, Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein, p45-Beckwith-Wiedemann region 1 A, ORCTL-2, p45-BWR1A

1 Images
Western blot - Anti-Solute carrier family 22 member 18 antibody (AB168960)
  • WB

Unknown

Western blot - Anti-Solute carrier family 22 member 18 antibody (AB168960)

All lanes:

Western blot - Anti-Solute carrier family 22 member 18 antibody (ab168960) at 1 µg/mL

Lane 1:

Solute carrier family 22 member 18 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 45 kDa

true

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human SLC22A18.

Q96BI1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Solute carrier family 22 member 18 (SLC22A18) also known as BWR1A is a transporter protein that plays a role in moving organic cations across cell membranes. It is a member of the solute carrier family 22 which includes several transporters that facilitate the movement of various molecules. The molecular mass of SLC22A18 is approximately 61 kDa. It is mostly expressed in tissues such as the kidney placenta and liver where it contributes to the regulation of extracellular and intracellular concentrations of organic ions.
Biological function summary

SLC22A18 functions in the uptake and extrusion of organic cations impacting cellular homeostasis and metabolism. It is not part of a complex but instead works individually within the cells. This protein helps in maintaining the balance of metabolites and xenobiotics substances foreign to an organism's body influencing processes including detoxification and metabolic regulation.

Pathways

SLC22A18 participates in the organic cation transport pathway and the xenobiotic metabolism pathway. It is related to proteins in these pathways such as other solute carriers which together maintain the transport of various cations and metabolites across cellular membranes. This action assists various cells in handling foreign substances by regulating their uptake and excretion to adapt to various internal and external environments.

SLC22A18 has associations with cancer and metabolic syndrome. Changes in its expression or function can affect cellular detoxification abilities which may lead to the development of certain cancers due to an accumulation of harmful compounds. In metabolic syndrome altered SLC22A18 function can disturb normal metabolism. This protein interacts with other solute carriers and transporters to influence disease progression through its key role in transporting critical molecules within the body.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney (PubMed : 9744804). Plays a role in the regulation of lipid metabolism (By similarity).
See full target information SLC22A18
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Pharmaceutical research 36:39 PubMed30635741

2019

Knockdown of Orphan Transporter SLC22A18 Impairs Lipid Metabolism and Increases Invasiveness of HepG2 Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Shingo Ito,Gentaro Honda,Yu Fujino,Seiryo Ogata,Mio Hirayama-Kurogi,Sumio Ohtsuki

Journal of pharmaceutical sciences 107:3163-3170 PubMed30145211

2018

Involvement of an Orphan Transporter, SLC22A18, in Cell Growth and Drug Resistance of Human Breast Cancer MCF7 Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Shingo Ito,Yu Fujino,Seiryo Ogata,Mio Hirayama-Kurogi,Sumio Ohtsuki
View all publications
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Product promise

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