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Rabbit Polyclonal Somatostatin Receptor 1/SSTR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SSTR1.

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Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human SSTR1. The exact immunogen used to generate this antibody is proprietary information. Database link P30872
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested
Mouse
Predicted
Rat
Predicted
Bat
Predicted
Cow
Predicted
Elephant
Predicted
Goat
Predicted
Hamster
Predicted
Horse
Predicted
Monkey
Predicted
Pig
Predicted
Rabbit
Predicted
Sheep
Predicted

Tested
Tested

Species

Human

Dilution info

-

Notes

Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.

Predicted
Predicted

Species

Mouse, Rat, Sheep, Rabbit, Goat, Horse, Hamster, Cow, Pig, Monkey, Bat, Elephant

Dilution info

-

Notes

-

Target data

Function

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

Alternative names

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Rabbit Polyclonal Somatostatin Receptor 1/SSTR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SSTR1.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human SSTR1. The exact immunogen used to generate this antibody is proprietary information. Database link P30872
Purification technique

Affinity purification Immunogen

Specificity

BLAST analysis of the peptide immunogen showed no homology with other proteins.

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological function summary

SSTR1 is important in the regulation of endocrine and neuronal signaling. It does not engage in complex formation but interacts through its pathways to inhibit hormone secretion. In neurons SSTR1 modulates neurotransmitter release impacting processes such as pain perception and neuronal growth. This function extends to controlling cell proliferation influencing cancer cells where it can suppress tumor growth by altering cell-cycle dynamics and inducing apoptosis.

Activity summary

Somatostatin Receptor 1 (SSTR1) is a G-protein coupled receptor that plays an important role in mediating the effects of the neuropeptide somatostatin. This receptor is often referred to simply as SSTR1 and has a molecular mass of approximately 42 kDa. SSTR1 gets expressed in numerous tissues including the brain kidney and lung. It is known to couple with inhibitory G-proteins leading to reduced adenylate cyclase activity and decreased levels of cyclic AMP which impacts cell signaling.

Pathways

SSTR1 plays its role in the somatostatin signaling pathway and the cAMP signaling pathway. Within these pathways it works along with proteins such as adenylate cyclase which it inhibits to relay somatostatin's signals effectively. SSTR1's ability to reduce cAMP levels makes it an important player in signal transduction pathways that govern cell function and communication.

Associated diseases and disorders

SSTR1 has relevance in conditions like acromegaly and neuroendocrine tumors. In acromegaly the receptor's ability to reduce growth hormone secretion is important for symptom management. SSTR1 also relates to neuroendocrine tumors through its interaction with somatostatin which can inhibit tumor growth and progression. In these contexts SSTR1's function intertwines with other somatostatin receptors like SSTR2 to modulate growth hormone release and cell proliferation in these diseases.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin Receptor 1/SSTR1 antibody (ab140945), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin Receptor 1/SSTR1 antibody (ab140945)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human pancreas islet, labelling Somatostatin Receptor 1/SSTR1 with ab140945.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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