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AB140945

Anti-Somatostatin Receptor 1/SSTR1 antibody

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(2 Publications)

Rabbit Polyclonal Somatostatin Receptor 1/SSTR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SSTR1.

View Alternative Names

Somatostatin receptor type 1, SS-1-R, SS1-R, SS1R, SST1, SRIF-2, SSTR1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin Receptor 1/SSTR1 antibody (AB140945)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin Receptor 1/SSTR1 antibody (AB140945)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human pancreas islet, labelling Somatostatin Receptor 1/SSTR1 with ab140945.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SSTR1. The exact immunogen used to generate this antibody is proprietary information.

P30872

Specificity

BLAST analysis of the peptide immunogen showed no homology with other proteins.

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Alternative Products

Primary Antibodies

AB100881

Anti-Somatostatin Receptor 1/SSTR1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Somatostatin Receptor 1/SSTR1 antibody (AB100881)

  • 1
  • 1
Primary Antibodies

AB137083

Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (AB137083)

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  • 1
Primary Antibodies

AB240103

Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] - BSA and Azide free (AB240103)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB109495

Anti-Somatostatin Receptor 5 antibody [UMB4]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin Receptor 5 antibody [UMB4] (AB109495)

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Primary Antibodies

AB134152

Anti-Somatostatin Receptor 2 antibody [UMB1] - C-terminal

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin Receptor 2 antibody [UMB1] - C-terminal (AB134152)

  • 0
  • 0
Primary Antibodies

AB108456

Anti-Somatostatin antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin antibody (AB108456)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Bat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Elephant": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Goat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Sheep": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Somatostatin Receptor 1 (SSTR1) is a G-protein coupled receptor that plays an important role in mediating the effects of the neuropeptide somatostatin. This receptor is often referred to simply as SSTR1 and has a molecular mass of approximately 42 kDa. SSTR1 gets expressed in numerous tissues including the brain kidney and lung. It is known to couple with inhibitory G-proteins leading to reduced adenylate cyclase activity and decreased levels of cyclic AMP which impacts cell signaling.
Biological function summary

SSTR1 is important in the regulation of endocrine and neuronal signaling. It does not engage in complex formation but interacts through its pathways to inhibit hormone secretion. In neurons SSTR1 modulates neurotransmitter release impacting processes such as pain perception and neuronal growth. This function extends to controlling cell proliferation influencing cancer cells where it can suppress tumor growth by altering cell-cycle dynamics and inducing apoptosis.

Pathways

SSTR1 plays its role in the somatostatin signaling pathway and the cAMP signaling pathway. Within these pathways it works along with proteins such as adenylate cyclase which it inhibits to relay somatostatin's signals effectively. SSTR1's ability to reduce cAMP levels makes it an important player in signal transduction pathways that govern cell function and communication.

SSTR1 has relevance in conditions like acromegaly and neuroendocrine tumors. In acromegaly the receptor's ability to reduce growth hormone secretion is important for symptom management. SSTR1 also relates to neuroendocrine tumors through its interaction with somatostatin which can inhibit tumor growth and progression. In these contexts SSTR1's function intertwines with other somatostatin receptors like SSTR2 to modulate growth hormone release and cell proliferation in these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
See full target information SSTR1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in molecular biosciences 8:794326 PubMed35155566

2022

Metastatic Immune-Related Genes for Affecting Prognosis and Immune Response in Renal Clear Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Si Sun,Weipu Mao,Lilin Wan,Kehao Pan,Liting Deng,Lei Zhang,Guangyuan Zhang,Ming Chen

Frontiers in physiology 12:673497 PubMed34733169

2021

Distribution of Cardiac and Renal Corin and Proprotein Convertase Subtilisin/Kexin-6 in the Experimental Model of Cardio-Renal Syndrome of Various Severities.

Applications

Unspecified application

Species

Unspecified reactive species

Emad E Khoury,Ahmad Fokra,Safa Kinaneh,Yara Knaney,Doron Aronson,Zaid Abassi
View all publications
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