Anti-Somatostatin Receptor 1/SSTR1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Somatostatin Receptor 1 (SSTR1) is a G-protein coupled receptor that plays an important role in mediating the effects of the neuropeptide somatostatin. This receptor is often referred to simply as SSTR1 and has a molecular mass of approximately 42 kDa. SSTR1 gets expressed in numerous tissues including the brain kidney and lung. It is known to couple with inhibitory G-proteins leading to reduced adenylate cyclase activity and decreased levels of cyclic AMP which impacts cell signaling.

Biological function summary

SSTR1 is important in the regulation of endocrine and neuronal signaling. It does not engage in complex formation but interacts through its pathways to inhibit hormone secretion. In neurons SSTR1 modulates neurotransmitter release impacting processes such as pain perception and neuronal growth. This function extends to controlling cell proliferation influencing cancer cells where it can suppress tumor growth by altering cell-cycle dynamics and inducing apoptosis.

Pathways

SSTR1 plays its role in the somatostatin signaling pathway and the cAMP signaling pathway. Within these pathways it works along with proteins such as adenylate cyclase which it inhibits to relay somatostatin's signals effectively. SSTR1's ability to reduce cAMP levels makes it an important player in signal transduction pathways that govern cell function and communication.

Associated diseases and disorders

SSTR1 has relevance in conditions like acromegaly and neuroendocrine tumors. In acromegaly the receptor's ability to reduce growth hormone secretion is important for symptom management. SSTR1 also relates to neuroendocrine tumors through its interaction with somatostatin which can inhibit tumor growth and progression. In these contexts SSTR1's function intertwines with other somatostatin receptors like SSTR2 to modulate growth hormone release and cell proliferation in these diseases.