AB137083

Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7]

Name: Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (ab137083) | Abcam
Brand: Abcam Limited
SKU: AB137083
Price: 580 USD
Availability: InStock
Rating: 5 (1 reviews)

RabMAb
Recombinant
What is this?

(1 Review)

(18 Publications)

Rabbit Recombinant Monoclonal Somatostatin Receptor 1/SSTR1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 18 publications.

View Alternative Names

Somatostatin receptor type 1, SS-1-R, SS1-R, SS1R, SST1, SRIF-2, SSTR1

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (AB137083)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (AB137083)

Immunofluorescent analysis of 2936E cells labelling Somatostatin Receptor 1/SSTR1 with ab137083 at 1/250 dilution.

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Western blot - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (AB137083)

All lanes:

Western blot - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (ab137083) at 1/500 dilution

Lane 1:

Human fetal lung lysates at 10 µg

Lane 2:

Human small intestine lysates at 10 µg

Secondary

All lanes:

goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 43 kDa

false

Carrier free

Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

UMB7

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/250 - 1/500", "ICCIF-species-notes": "" } } }

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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.31% Sodium citrate, 0.175% Sodium chloride, 0.05% BSA, 0.0172% EDTA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Somatostatin Receptor 1 (SSTR1) is a G-protein coupled receptor that plays an important role in mediating the effects of the neuropeptide somatostatin. This receptor is often referred to simply as SSTR1 and has a molecular mass of approximately 42 kDa. SSTR1 gets expressed in numerous tissues including the brain kidney and lung. It is known to couple with inhibitory G-proteins leading to reduced adenylate cyclase activity and decreased levels of cyclic AMP which impacts cell signaling.

Biological function summary

SSTR1 is important in the regulation of endocrine and neuronal signaling. It does not engage in complex formation but interacts through its pathways to inhibit hormone secretion. In neurons SSTR1 modulates neurotransmitter release impacting processes such as pain perception and neuronal growth. This function extends to controlling cell proliferation influencing cancer cells where it can suppress tumor growth by altering cell-cycle dynamics and inducing apoptosis.

Pathways

SSTR1 plays its role in the somatostatin signaling pathway and the cAMP signaling pathway. Within these pathways it works along with proteins such as adenylate cyclase which it inhibits to relay somatostatin's signals effectively. SSTR1's ability to reduce cAMP levels makes it an important player in signal transduction pathways that govern cell function and communication.

SSTR1 has relevance in conditions like acromegaly and neuroendocrine tumors. In acromegaly the receptor's ability to reduce growth hormone secretion is important for symptom management. SSTR1 also relates to neuroendocrine tumors through its interaction with somatostatin which can inhibit tumor growth and progression. In these contexts SSTR1's function intertwines with other somatostatin receptors like SSTR2 to modulate growth hormone release and cell proliferation in these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

See full target information SSTR1

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Publications (18)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular life sciences : CMLS 82:173 PubMed40268793

2025

Assessing the diagnostic, prognostic, and therapeutic potential of the somatostatin/cortistatin system in glioblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Miguel E G-García,Ana S De la Rosa-Herencia,Álvaro Flores-Martínez,María Ortega-Bellido,Rafael Sánchez-Sánchez,Cristóbal Blanco-Acevedo,Manuel D Gahete,Juan Solivera,Raúl M Luque,Antonio C Fuentes-Fayos

Cancers 16: PubMed39272962

2024

Immune Cell Molecular Pharmacodynamics of Lanreotide in Relation to Treatment Response in Patients with Gastroenteropancreatic Neuroendocrine Tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Sabah Alaklabi,Orla Maguire,Harsha Pattnaik,Yali Zhang,Jacky Chow,Jianmin Wang,Hans Minderman,Renuka Iyer

PloS one 19:e0304813 PubMed39038008

2024

Somatostatin receptors in fibrotic myocardium.

Applications

Unspecified application

Species

Unspecified reactive species

Estibaliz Castillero,Chiara Camillo,W Clinton Erwin,Sameer Singh,Nafisa Mohamoud,Isaac George,Elizabeth Eapen,Keith Dockery,Giovanni Ferrari,Himanshu Gupta

BMC endocrine disorders 22:184 PubMed35854271

2022

Ectopic ACTH-producing neuroendocrine tumor occurring with large recurrent metastatic pheochromocytoma: a case report.

Applications

Unspecified application

Species

Unspecified reactive species

Fumi Saishouji,Sarie Maeda,Hideaki Hamada,Noriko Kimura,Ai Tamanoi,Saiko Nishida,Masaji Sakaguchi,Motoyuki Igata,Kiho Yokoo,Fumi Kawakami,Eiichi Araki,Tatsuya Kondo

Cancers 14: PubMed35008325

2021

Correlation of Somatostatin Receptor 1-5 Expression, [Ga]Ga-DOTANOC, [F]F-FDG PET/CT and Clinical Outcome in a Prospective Cohort of Pancreatic Neuroendocrine Neoplasms.

Applications

Unspecified application

Species

Unspecified reactive species

Susanna Majala,Tiina Vesterinen,Hanna Seppänen,Harri Mustonen,Jari Sundström,Camilla Schalin-Jäntti,Risto Gullichsen,Jukka Schildt,Jukka Kemppainen,Johanna Arola,Saila Kauhanen

Journal of clinical medicine 9: PubMed32971845

2020

Quantitative Analysis of Somatostatin and Dopamine Receptors Gene Expression Levels in Non-functioning Pituitary Tumors and Association with Clinical and Molecular Aggressiveness Features.

Applications

Unspecified application

Species

Unspecified reactive species

Álvaro Flores-Martinez,Eva Venegas-Moreno,Elena Dios,Pablo Remón-Ruiz,Noelia Gros-Herguido,M Carmen Vázquez-Borrego,Ainara Madrazo-Atutxa,Miguel A Japón,Ariel Kaen,Eugenio Cárdenas-Valdepeñas,Florinda Roldán,Justo P Castaño,Raúl M Luque,David A Cano,Alfonso Soto-Moreno

Seizure 76:123-130 PubMed32062323

2020

Somatostatin receptor expression and mTOR pathway activation in glioneuronal tumours of childhood.

Applications

Unspecified application

Species

Unspecified reactive species

Christoffer Ehrstedt,Gunnar Ahlsten,Bo Strömberg,Cecilia Lindskog,Olivera Casar-Borota

Endocrine connections 8:1213-1223 PubMed31336364

2019

Somatostatin receptor expression in parathyroid neoplasms.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Storvall,Helena Leijon,Eeva Ryhänen,Johanna Louhimo,Caj Haglund,Camilla Schalin-Jäntti,Johanna Arola

The journal of histochemistry and cytochemistry : 67:735-743 PubMed31381461

2019

Immunohistochemical Expression of Somatostatin Receptor Subtypes in a Panel of Neuroendocrine Neoplasias.

Applications

Unspecified application

Species

Unspecified reactive species

Satu M Remes,Helena L Leijon,Tiina J Vesterinen,Johanna T Arola,Caj H Haglund

Oncology letters 17:1723-1731 PubMed30675231

2019

Expression and selective activation of somatostatin receptor subtypes induces cell cycle arrest in cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Zou,Haiping Tan,Yuanfeng Zhao,Yuan Zhou,Lin Cao

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7]

Immunocytochemistry/ Immunofluorescence - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (AB137083)

Western blot - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] (AB137083)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Primary Antibodies

Secondary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (18)

Product promise