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AB28680

Anti-Somatostatin Receptor 3/SSTR3 antibody

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(4 Publications)

Rabbit Polyclonal Somatostatin Receptor 3/SSTR3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human SSTR3 aa 350-400.

View Alternative Names

Somatostatin receptor type 3, SS-3-R, SS3-R, SS3R, SST3, SSR-28, SSTR3

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin Receptor 3/SSTR3 antibody (AB28680)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin Receptor 3/SSTR3 antibody (AB28680)

ab28680, at a dilution of 1/2500, staining Human pancreatic islands by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SSTR3 aa 350-400. The exact immunogen used to generate this antibody is proprietary information.

P32745

Specificity

Ab28680 detects Somatostatin Receptor 3/SSTR3.

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/2500", "IHCP-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Preservative: 0.05% Sodium azide Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Somatostatin Receptor 3 (SSTR3) also known as SS3R or SRIF1C is a G-protein-coupled receptor with an estimated mass of around 45 kDa. This receptor specifically binds the peptide hormone somatostatin leading to a variety of intracellular responses. Located primarily in the central nervous system SSTR3 is particularly concentrated in the hypothalamus and hippocampus though it also appears in peripheral tissues like the pancreas and gastrointestinal tract. The receptor transmits signals that involve inhibition of adenylyl cyclase and activation of phosphotyrosine phosphatases.
Biological function summary

SSTR3 plays an important role in inhibiting the release of several other hormones and neurotransmitters like growth hormone and glucagon which helps regulate endocrine and nervous system activities. It functions as part of a complex system that includes other somatostatin receptors. By interacting with these systems SSTR3 influences processes such as cell proliferation neurotransmission and the modulation of cyclic AMP levels. Due to its inhibitory function the receptor helps maintain balance in hormone secretion and neural activity.

Pathways

SSTR3 receptor signaling integrates into the somatostatin signaling pathway an important process in hormone secretion regulation. It works closely with other receptors like SSTR2 together mediating somatostatin effects throughout the body. The receptor is also involved in the MAPK signaling pathway which has roles in cellular responses to various stimuli. These pathways contribute to its ability to modulate growth apoptosis and neuronal signaling.

SSTR3 has associations with neurodegenerative diseases such as Alzheimer’s disease due to its role in the central nervous system and neuroprotection. Changes or dysfunctions in SSTR3 expression can influence the progression of these conditions. The receptor’s interaction with other proteins like amyloid-beta peptide links it to the pathophysiology of Alzheimer’s. Additionally SSTR3 has a role in pituitary adenomas influencing growth hormone secretion patterns. This involves interaction with growth hormone-releasing hormone highlighting its impact on endocrine disorders.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
See full target information SSTR3

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of neuroendocrinology 34:e13109 PubMed35304807

2022

Combined use of Lu-DOTATATE peptide receptor radionuclide therapy and fluzoparib for treatment of well-differentiated neuroendocrine tumors: A preclinical study.

Applications

Unspecified application

Species

Unspecified reactive species

Jingjing Fu,Fan Qiu,Cati Raluca Stolniceanu,Fei Yu,Shiming Zang,Yili Xiang,Yue Huang,Milovan Matovic,Cipriana Stefanescu,Qiyun Tang,Feng Wang

EJNMMI research 5:25 PubMed25977882

2015

Somatostatin receptor subtype 2 in high-grade gliomas: PET/CT with (68)Ga-DOTA-peptides, correlation to prognostic markers, and implications for targeted radiotherapy.

Applications

IHC

Species

Unspecified reactive species

Aida Kiviniemi,Maria Gardberg,Janek Frantzén,Marko Pesola,Ville Vuorinen,Riitta Parkkola,Tuula Tolvanen,Sami Suilamo,Jarkko Johansson,Pauliina Luoto,Jukka Kemppainen,Anne Roivainen,Heikki Minn

Annals of oncology : official journal of the Europ 21:548-555 PubMed19759190

2009

Somatostatin receptor tissue distribution in lung neuroendocrine tumours: a clinicopathologic and immunohistochemical study of 218 'clinically aggressive' cases.

Applications

IHC

Species

Human

L Righi,M Volante,V Tavaglione,A Billè,L Daniele,T Angusti,F Inzani,G Pelosi,G Rindi,M Papotti

Modern pathology : an official journal of the Unit 20:1172-82 PubMed17873898

2007

Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: a proposal of scoring system correlated with somatostatin receptor scintigraphy.

Applications

Unspecified application

Species

Unspecified reactive species

Marco Volante,Maria Pia Brizzi,Antongiulio Faggiano,Stefano La Rosa,Ida Rapa,Anna Ferrero,Gelsomina Mansueto,Luisella Righi,Silvana Garancini,Carlo Capella,Gaetano De Rosa,Luigi Dogliotti,Annamaria Colao,Mauro Papotti
View all publications

Product promise

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