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AB216020

Anti-SOX10 antibody [SOX10/1074]

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(14 Publications)

Mouse Monoclonal SOX10 antibody. Suitable for IHC-P, WB, Protein Array and reacts with Mouse, Human, Recombinant fragment samples. Cited in 14 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SOX10 aa 100-300.

View Alternative Names

Transcription factor SOX-10, SOX10

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX10 antibody [SOX10/1074] (AB216020)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX10 antibody [SOX10/1074] (AB216020)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human melanoma tissue labeling SOX10 with ab216020 at 1 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX10 antibody [SOX10/1074] (AB216020)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX10 antibody [SOX10/1074] (AB216020)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse brain tissue labeling SOX10 with ab216020 at 1 μg/ml.

Protein Array - Anti-SOX10 antibody [SOX10/1074] (AB216020)
  • Protein Array

Unknown

Protein Array - Anti-SOX10 antibody [SOX10/1074] (AB216020)

ab216020 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Western blot - Anti-SOX10 antibody [SOX10/1074] (AB216020)
  • WB

Supplier Data

Western blot - Anti-SOX10 antibody [SOX10/1074] (AB216020)

All lanes:

Western blot - Anti-SOX10 antibody [SOX10/1074] (ab216020) at 1 µg/mL

Lane 1:

Recombinant fragment Human SOX10 aa 115-269

Lane 2:

A375 cell lysate

Predicted band size: 49 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

SOX10/1074

Isotype

IgG2b

Light chain type

kappa

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, Protein Array, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SOX10 aa 100-300. The exact immunogen used to generate this antibody is proprietary information.

P56693

Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
ab216020 was purified from Bioreactor Concentrate by Protein A/G.
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed : 21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity).
See full target information SOX10

Publications (14)

Recent publications for all applications. Explore the full list and refine your search

Alzheimer's research & therapy 17:109 PubMed40394655

2025

Cannabidiol as a multifaceted therapeutic agent: mitigating Alzheimer's disease pathology and enhancing cognitive function.

Applications

Unspecified application

Species

Unspecified reactive species

Iu Raïch,Jaume Lillo,Joan Biel Rebassa,Christian Griñán-Ferré,Aina Bellver-Sanchis,Irene Reyes-Resina,Rafael Franco,Mercè Pallàs,Gemma Navarro

Nature communications 16:515 PubMed39779705

2025

Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8.

Applications

Unspecified application

Species

Unspecified reactive species

Nadège Hertzog,Mert Duman,Maëlle Bochud,Valérie Brügger-Verdon,Maren Gerhards,Felicia Schön,Franka Dorndecker,Dies Meijer,Robert Fledrich,Ruth Stassart,Devanarayanan Siva Sankar,Jörn Dengjel,Sofía Raigón López,Claire Jacob

Neural development 19:1 PubMed38167468

2024

Loss of G9a does not phenocopy the requirement for Prdm12 in the development of the nociceptive neuron lineage.

Applications

Unspecified application

Species

Unspecified reactive species

Panagiotis Tsimpos,Simon Desiderio,Pauline Cabochette,Philippe Poelvoorde,Sadia Kricha,Luc Vanhamme,Coralie Poulard,Eric J Bellefroid

iScience 26:108364 PubMed38025786

2023

Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia.

Applications

Unspecified application

Species

Unspecified reactive species

Simon Vermeiren,Pauline Cabochette,Maya Dannawi,Simon Desiderio,Alba Sabaté San José,Younes Achouri,Sadia Kricha,Maren Sitte,Gabriela Salinas-Riester,Benoit Vanhollebeke,Jean-François Brunet,Eric J Bellefroid

Frontiers in neuroscience 17:1250547 PubMed37937069

2023

Antibody-recognizing residues 188-211 of TMEM106B exhibit immunohistochemical reactivity with the TMEM106B C-terminal fragment.

Applications

Unspecified application

Species

Unspecified reactive species

Ruoyi Ishikawa,Yu Yamazaki,Masahiro Nakamori,Tetsuya Takahashi,Hirofumi Maruyama

Scientific reports 13:4670 PubMed36949072

2023

Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Breanna Q Shen,Ishwarya Sankaranarayanan,Theodore J Price,Diana Tavares-Ferreira

Theranostics 12:7307-7318 PubMed36438492

2022

Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxia Sun,Xiang Chen,Cen Yue,Wenyi Yang,Shu Zhang,Zhimin Ou,Ying Chen

Theranostics 12:5470-5487 PubMed35910794

2022

Dedifferentiated Schwann cell-derived TGF-β3 is essential for the neural system to promote wound healing.

Applications

Unspecified application

Species

Unspecified reactive species

Min-Yi Ou,Poh-Ching Tan,Yun Xie,Kai Liu,Yi-Ming Gao,Xiao-Sheng Yang,Shuang-Bai Zhou,Qing-Feng Li

Nature communications 13:3732 PubMed35768444

2022

Inactivation of the Hippo tumor suppressor pathway promotes melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Marc A Vittoria,Nathan Kingston,Kristyna Kotynkova,Eric Xia,Rui Hong,Lee Huang,Shayna McDonald,Andrew Tilston-Lunel,Revati Darp,Joshua D Campbell,Deborah Lang,Xiaowei Xu,Craig J Ceol,Xaralabos Varelas,Neil J Ganem

Molecular therapy. Methods & clinical development 26:169-180 PubMed35846573

2022

Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2.

Applications

Unspecified application

Species

Unspecified reactive species

Shilpa Prabhakar,Roberta L Beauchamp,Pike See Cheah,Akiko Yoshinaga,Edwina Abou Haidar,Sevda Lule,Gayathri Mani,Katia Maalouf,Anat Stemmer-Rachamimov,David H Jung,D Bradley Welling,Marco Giovannini,Scott R Plotkin,Casey A Maguire,Vijaya Ramesh,Xandra O Breakefield
View all publications

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