Mouse Monoclonal SOX10 antibody. Suitable for IHC-P, WB, Protein Array and reacts with Mouse, Human, Recombinant fragment samples. Cited in 11 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SOX10 aa 100-300.
Images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX10 antibody [SOX10/1074] (AB216020), expandable thumbnail](https://content.abcam.com/products/images/sox10-antibody-sox10-1074-ab216020--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img56845.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX10 antibody [SOX10/1074] (AB216020)")
![Western blot - Anti-SOX10 antibody [SOX10/1074] (AB216020), expandable thumbnail](https://content.abcam.com/products/images/sox10-antibody-sox10-1074-ab216020--western-blot-img93277.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-SOX10 antibody [SOX10/1074] (AB216020)")
![Protein Array - Anti-SOX10 antibody [SOX10/1074] (AB216020), expandable thumbnail](https://content.abcam.com/products/images/sox10-antibody-sox10-1074-ab216020--protein-array-img140577.jpg/_jcr_content/renditions/webp-475.webp "Protein Array - Anti-SOX10 antibody [SOX10/1074] (AB216020)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX10 antibody [SOX10/1074] (AB216020), expandable thumbnail](https://content.abcam.com/products/images/sox10-antibody-sox10-1074-ab216020--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img42938.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX10 antibody [SOX10/1074] (AB216020)")
Publications
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- iScience 26:1083642023Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSimon Vermeiren,Pauline Cabochette,Maya Dannawi,Simon Desiderio,Alba Sabaté San José,Younes Achouri,Sadia Kricha,Maren Sitte,Gabriela Salinas-Riester,Benoit Vanhollebeke,Jean-François Brunet,Eric J BellefroidPubMed 38025786
- Frontiers in neuroscience 17:12505472023Antibody-recognizing residues 188-211 of TMEM106B exhibit immunohistochemical reactivity with the TMEM106B C-terminal fragment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRuoyi Ishikawa,Yu Yamazaki,Masahiro Nakamori,Tetsuya Takahashi,Hirofumi MaruyamaPubMed 37937069
- Scientific reports 13:46702023Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBreanna Q Shen,Ishwarya Sankaranarayanan,Theodore J Price,Diana Tavares-FerreiraPubMed 36949072
- Theranostics 12:7307-73182022Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuxia Sun,Xiang Chen,Cen Yue,Wenyi Yang,Shu Zhang,Zhimin Ou,Ying ChenPubMed 36438492
- Theranostics 12:5470-54872022Dedifferentiated Schwann cell-derived TGF-β3 is essential for the neural system to promote wound healing.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMin-Yi Ou,Poh-Ching Tan,Yun Xie,Kai Liu,Yi-Ming Gao,Xiao-Sheng Yang,Shuang-Bai Zhou,Qing-Feng LiPubMed 35910794
- Nature communications 13:37322022Inactivation of the Hippo tumor suppressor pathway promotes melanoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarc A Vittoria,Nathan Kingston,Kristyna Kotynkova,Eric Xia,Rui Hong,Lee Huang,Shayna McDonald,Andrew Tilston-Lunel,Revati Darp,Joshua D Campbell,Deborah Lang,Xiaowei Xu,Craig J Ceol,Xaralabos Varelas,Neil J GanemPubMed 35768444
- Molecular therapy. Methods & clinical development 26:169-1802022Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShilpa Prabhakar,Roberta L Beauchamp,Pike See Cheah,Akiko Yoshinaga,Edwina Abou Haidar,Sevda Lule,Gayathri Mani,Katia Maalouf,Anat Stemmer-Rachamimov,David H Jung,D Bradley Welling,Marco Giovannini,Scott R Plotkin,Casey A Maguire,Vijaya Ramesh,Xandra O BreakefieldPubMed 35846573
- Nature communications 11:34202020EEF1A1 deacetylation enables transcriptional activation of remyelination.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMert Duman et. al.PubMed 32647127
- Neoplasia (New York, N.Y.) 22:376-3892020BRAF inhibition in melanoma is associated with the dysregulation of histone methylation and histone methyltransferases.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFlorina Grigore et. al.PubMed 32629178
- Brain, behavior, and immunity 88:535-5462020Macrophages and Schwann cell TRPA1 mediate chronic allodynia in a mouse model of complex regional pain syndrome type I.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFrancesco De Logu et. al.PubMed 32315759
Key facts
- Isotype
- IgG2b
- Host species
- Mouse
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Recombinant Fragment Protein within Human SOX10 aa 100-300. The exact immunogen used to generate this antibody is proprietary information. Database link P56693
Consider this alternative
Reactivity data
Select an application| IHC-P | WB | Protein Array | |
|---|---|---|---|
| Human | Tested | Expected | Tested |
| Mouse | Tested | Tested | Expected |
| Recombinant fragment | Expected | Expected | Expected |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1-2 µg/mL | Notes (Primary incubation for 30 minutes at RT). Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
Species Human | Dilution info 1-2 µg/mL | Notes (Primary incubation for 30 minutes at RT). Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant fragment | Dilution info 1-2 µg/mL | Notes (Primary incubation for 30 minutes at RT). |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1-2 µg/mL | Notes Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Species Recombinant fragment | Dilution info 1-2 µg/mL | Notes - |
Protein Array
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Recombinant fragment | Dilution info Use at an assay dependent concentration. | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Version
6 products for Alternative Product
Target data
Function
Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity).
Alternative names
Transcription factor SOX-10, SOX10
Recommended products
Mouse Monoclonal SOX10 antibody. Suitable for IHC-P, WB, Protein Array and reacts with Mouse, Human, Recombinant fragment samples. Cited in 11 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SOX10 aa 100-300.
Key facts
- Isotype
- IgG2b
- Host species
- Mouse
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Recombinant Fragment Protein within Human SOX10 aa 100-300. The exact immunogen used to generate this antibody is proprietary information. Database link P56693
- Clone number
- SOX10/1074
- Purification technique
- Affinity purification Protein A
- Light chain type
- kappa
- Concentration
- Purification notes
ab216020 was purified from Bioreactor Concentrate by Protein A/G.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
4 product images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX10 antibody [SOX10/1074] (ab216020), expandable thumbnail](https://content.abcam.com/products/images/sox10-antibody-sox10-1074-ab216020--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img56845.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX10 antibody [SOX10/1074] (ab216020)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX10 antibody [SOX10/1074] (ab216020)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human melanoma tissue labeling SOX10 with ab216020 at 1 μg/ml.
![Western blot - Anti-SOX10 antibody [SOX10/1074] (ab216020), expandable thumbnail](https://content.abcam.com/products/images/sox10-antibody-sox10-1074-ab216020--western-blot-img93277.jpg "Western blot - Anti-SOX10 antibody [SOX10/1074] (ab216020)")
Western blot - Anti-SOX10 antibody [SOX10/1074] (ab216020)
All lanes: Western blot - Anti-SOX10 antibody [SOX10/1074] (ab216020) at 1 µg/mL
Lane 1: Recombinant fragment Human SOX10 aa 115-269
Lane 2: A375 cell lysate
Predicted band size: 49 kDa
![Protein Array - Anti-SOX10 antibody [SOX10/1074] (ab216020), expandable thumbnail](https://content.abcam.com/products/images/sox10-antibody-sox10-1074-ab216020--protein-array-img140577.jpg "Protein Array - Anti-SOX10 antibody [SOX10/1074] (ab216020)")
Protein Array - Anti-SOX10 antibody [SOX10/1074] (ab216020)
ab216020 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX10 antibody [SOX10/1074] (ab216020), expandable thumbnail](https://content.abcam.com/products/images/sox10-antibody-sox10-1074-ab216020--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img42938.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX10 antibody [SOX10/1074] (ab216020)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX10 antibody [SOX10/1074] (ab216020)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse brain tissue labeling SOX10 with ab216020 at 1 μg/ml.
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