Rabbit Recombinant Monoclonal SOX11 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 8 publications.
Images
![Immunoprecipitation - Anti-SOX11 antibody [EPR8192] (AB134107), expandable thumbnail](https://content.abcam.com/products/images/sox11-antibody-epr8192-ab134107--immunoprecipitation-img179931.jpg/_jcr_content/renditions/webp-475.webp "Immunoprecipitation - Anti-SOX11 antibody [EPR8192] (AB134107)")
![Western blot - Anti-SOX11 antibody [EPR8192] (AB134107), expandable thumbnail](https://content.abcam.com/products/images/sox11-antibody-epr8192-ab134107--western-blot-img125625.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-SOX11 antibody [EPR8192] (AB134107)")
![OI-RD Scanning - Anti-SOX11 antibody [EPR8192] (AB134107), expandable thumbnail](https://content.abcam.com/products/images/sox11-antibody-epr8192-ab134107--oi-rd-scanning-img137797.jpg/_jcr_content/renditions/webp-475.webp "OI-RD Scanning - Anti-SOX11 antibody [EPR8192] (AB134107)")
Publications
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- Disease models & mechanisms 14:2021Sox11 regulates mammary tumour-initiating and metastatic capacity in Brca1-deficient mouse mammary tumour cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSiu Man Tsang,Hyojin Kim,Erik Oliemuller,Richard Newman,Naa-Anyima Boateng,Naomi Guppy,Beatrice A HowardPubMed 33969421
- Oncology reports 44:1511-15232020lncRNA PCNAP1 predicts poor prognosis in breast cancer and promotes cancer metastasis via miR‑340‑5p‑dependent upregulation of SOX4.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYang Yu et. al.PubMed 32945462
- BMC cancer 19:6192019Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJohn A Smestad et. al.PubMed 31234811
- Cell reports 25:2689-2703.e32018Single-Cell RNA-Seq of Mouse Olfactory Bulb Reveals Cellular Heterogeneity and Activity-Dependent Molecular Census of Adult-Born Neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBurak Tepe,Matthew C Hill,Brandon T Pekarek,Patrick J Hunt,Thomas J Martin,James F Martin,Benjamin R ArenkielPubMed 30517858
- Scientific reports 8:161962018Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesElli-Anna Balta et. al.PubMed 30385877
- Frontiers in molecular neuroscience 11:2112018Phosphorylation Modulates the Subcellular Localization of SOX11.Applications:Unspecified applicationReactive species:Unspecified reactive speciesElli-Anna Balta et. al.PubMed 29973868
- Journal of neurochemistry 146:251-2682018The transcription factor prospero homeobox protein 1 is a direct target of SoxC proteins during developmental vertebrate neurogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnne Jacob,Hannah M Wüst,Johannes M Thalhammer,Franziska Fröb,Melanie Küspert,Simone Reiprich,Elli-Anna Balta,D Chichung Lie,Michael Wegner,Elisabeth SockPubMed 29749639
- Molecular therapy : the journal of the American So 26:1299-13122018miR-223-3p Inhibits Human Osteosarcoma Metastasis and Progression by Directly Targeting CDH6.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQuanbo Ji et. al.PubMed 29628305
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.01% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| ICC/IF | IP | Flow Cyt | WB | IHC-P | |
|---|---|---|---|---|---|
| Human | Not recommended | Tested | Not recommended | Tested | Not recommended |
ICC/IF
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
IP
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/10 - 1/100 | Notes - |
Flow Cyt
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000 - 1/10000 | Notes - |
IHC-P
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Associated Products
Select an associated product type
8 products for Alternative Product
Target data
Function
Transcription factor that acts as a transcriptional activator (PubMed:24886874, PubMed:26543203). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity).
Alternative names
Transcription factor SOX-11, SOX11
Recommended products
Rabbit Recombinant Monoclonal SOX11 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 8 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.01% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Clone number
- EPR8192
- Purification technique
- Affinity purification Protein A
- Dissociation constant
- 3.7 x 10-11 M
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Stable for 12 months at -20°C
Notes
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
3 product images
![Immunoprecipitation - Anti-SOX11 antibody [EPR8192] (ab134107), expandable thumbnail](https://content.abcam.com/products/images/sox11-antibody-epr8192-ab134107--immunoprecipitation-img179931.jpg "Immunoprecipitation - Anti-SOX11 antibody [EPR8192] (ab134107)")
Immunoprecipitation - Anti-SOX11 antibody [EPR8192] (ab134107)
SOX11 was immunoprecipitated from 0.35 mg Y79 (Human retinoblastoma retinoblastoma) whole cell lysate 10 μg with 134107 at 1/40 dilution (2μg). VeriBlot for IP Detection Reagent (HRP)(VeriBlot for IP Detection Reagent (HRP) ab131366) was used at 1/5000 dilution.
Lane 1: Y79 (Human retinoblastoma retinoblastoma) whole cell lysate 10 μg
Lane 2: ab134107 IP in Y79 whole cell lysate
Lane 3: Rabbit monoclonal IgG (Rabbit IgG, monoclonal [EPR25A] - Isotype Control ab172730) instead of ab134107 in Y79 whole cell lysate
Blocking and dilution buffer and concentration: 5% NFDM/TBST.
All lanes: Immunoprecipitation - Anti-SOX11 antibody [EPR8192] (ab134107)
Predicted band size: 47 kDa
Observed band size: 60 kDa
![Western blot - Anti-SOX11 antibody [EPR8192] (ab134107), expandable thumbnail](https://content.abcam.com/products/images/sox11-antibody-epr8192-ab134107--western-blot-img125625.jpg "Western blot - Anti-SOX11 antibody [EPR8192] (ab134107)")
Western blot - Anti-SOX11 antibody [EPR8192] (ab134107)
All lanes: Western blot - Anti-SOX11 antibody [EPR8192] (ab134107) at 1/1000 dilution
Lane 1: Human fetal brain lysate at 10 µg
Lane 2: Y-79 cell lysate at 10 µg
SecondaryAll lanes: HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 47 kDa
Observed band size: 60 kDa
![OI-RD Scanning - Anti-SOX11 antibody [EPR8192] (ab134107), expandable thumbnail](https://content.abcam.com/products/images/sox11-antibody-epr8192-ab134107--oi-rd-scanning-img137797.jpg "OI-RD Scanning - Anti-SOX11 antibody [EPR8192] (ab134107)")
OI-RD Scanning - Anti-SOX11 antibody [EPR8192] (ab134107)
We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody.
Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.
Downloads
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