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Rabbit Polyclonal SOX9A antibody. N-terminal. Suitable for IHC - Wmt and reacts with Zebrafish samples. Cited in 1 publication.

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Images

IHC - Wholemount - Anti-Sox9a antibody - N-terminal (AB209820), expandable thumbnail

Publications

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)

Form
Liquid
Clonality
Polyclonal

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC - Wmt
Zebrafish
Tested

Tested
Tested

Species
Zebrafish
Dilution info
-
Notes

-

Target data

Alternative names

HMG box transcription factor Sox9a, Jef, Jellyfish, SRY (sex determining region Y)-box 9a, SRY box containing gene 9a, Transcription factor sox9a, wu:fj17b12, zgc:111921

Recommended products

Rabbit Polyclonal SOX9A antibody. N-terminal. Suitable for IHC - Wmt and reacts with Zebrafish samples. Cited in 1 publication.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Purification technique
Affinity purification Immunogen
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

Sox9a also known simply as Sox9 is a transcription factor with a mass of approximately 57 kDa. It acts mechanically by binding to DNA sequences to regulate the expression of various genes. This protein belongs to the SRY-related HMG-box (Sox) family which plays a part in the control of embryonic development and cell fate decisions. Sox9a is expressed in several tissues including the cartilage heart gonads and central nervous system showing its diverse role across different body parts.

Biological function summary

Sox9a is involved in several important developmental processes. It regulates chondrogenesis the process of cartilage formation where it interacts with other proteins as part of multimeric complexes. It also plays a part in sex determination by promoting the development of Sertoli cells in testes affecting male gonad differentiation. Sox9a's function in the regulation of stem cells signifies its regulatory potential in tissue renewal and repair mechanisms.

Pathways

Sox9a plays a role in both the TGF-beta and Wnt signaling pathways essential for the differentiation and proliferation of cells. In the TGF-beta pathway Sox9a works closely with Smad3 to influence the transcription of genes necessary for chondrocyte differentiation. In the context of the Wnt signaling pathway Sox9a interacts with β-catenin being part of a regulatory network that affects skeletal development and repair.

Associated diseases and disorders

Abnormalities in Sox9a function or expression relate to campomelic dysplasia a disorder characterized by skeletal malformations and sex reversal. Mutations in Sox9a lead to defective cartilage development and improper sexual differentiation. Another related condition is Pierre Robin sequence often featuring craniofacial anomalies which involve disruptions in skeletal and craniofacial development pathways where Sox9a and the protein RUNX2 have roles in bone formation.

Product promise

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1 product image

  • IHC - Wholemount - Anti-Sox9a antibody - N-terminal (ab209820), expandable thumbnail

    IHC - Wholemount - Anti-Sox9a antibody - N-terminal (ab209820)

    Immunohistochemical analysis (whole mount) of paraformaldehyde-fixed Zebrafish embryo labeling Sox9a with ab209820 at 1/200 dilution.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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