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AB209820

Anti-Sox9a antibody - N-terminal

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(3 Publications)

Rabbit Polyclonal SOX9A antibody. N-terminal. Suitable for IHC - Wmt and reacts with Zebrafish samples. Cited in 3 publications.

View Alternative Names

HMG box transcription factor Sox9a, Jef, Jellyfish, SRY (sex determining region Y)-box 9a, SRY box containing gene 9a, Transcription factor sox9a, wu:fj17b12, zgc:111921

1 Images
IHC - Wholemount - Anti-Sox9a antibody - N-terminal (AB209820)
  • IHC - Wmt

Supplier Data

IHC - Wholemount - Anti-Sox9a antibody - N-terminal (AB209820)

Sox9a antibody detects Sox9a protein on whole mount zebrafish by immunohistochemical analysis.
ab209820 was used at a 1/200 dilution.
Antigen Retrieval : Tris-HCl buffer, pH 9.0, 20 min at 70°C

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Zebrafish

Applications

IHC - Wmt

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCWmt" : {"fullname" : "IHC - Wholemount", "shortname":"IHC - Wmt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Zebrafish": { "IHCWmt-species-checked": "testedAndGuaranteed", "IHCWmt-species-dilution-info": "1/100 - 1/500", "IHCWmt-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Sox9a also known simply as Sox9 is a transcription factor with a mass of approximately 57 kDa. It acts mechanically by binding to DNA sequences to regulate the expression of various genes. This protein belongs to the SRY-related HMG-box (Sox) family which plays a part in the control of embryonic development and cell fate decisions. Sox9a is expressed in several tissues including the cartilage heart gonads and central nervous system showing its diverse role across different body parts.
Biological function summary

Sox9a is involved in several important developmental processes. It regulates chondrogenesis the process of cartilage formation where it interacts with other proteins as part of multimeric complexes. It also plays a part in sex determination by promoting the development of Sertoli cells in testes affecting male gonad differentiation. Sox9a's function in the regulation of stem cells signifies its regulatory potential in tissue renewal and repair mechanisms.

Pathways

Sox9a plays a role in both the TGF-beta and Wnt signaling pathways essential for the differentiation and proliferation of cells. In the TGF-beta pathway Sox9a works closely with Smad3 to influence the transcription of genes necessary for chondrocyte differentiation. In the context of the Wnt signaling pathway Sox9a interacts with β-catenin being part of a regulatory network that affects skeletal development and repair.

Abnormalities in Sox9a function or expression relate to campomelic dysplasia a disorder characterized by skeletal malformations and sex reversal. Mutations in Sox9a lead to defective cartilage development and improper sexual differentiation. Another related condition is Pierre Robin sequence often featuring craniofacial anomalies which involve disruptions in skeletal and craniofacial development pathways where Sox9a and the protein RUNX2 have roles in bone formation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Sox9a
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Biology 14: PubMed40906377

2025

Functional Spermatogenesis Across Testicular Developmental Stages in Neomale Large Yellow Croaker () Revealed by Histology and Gonadal Specific Cellular Markers.

Applications

Unspecified application

Species

Unspecified reactive species

Xu Liu,Weihua Hu,Ruiyi Chen,Yang Yang,Sixian Yang,Dongdong Xu

Communications biology 8:514 PubMed40155473

2025

Defining gastric cancer ecology: the crucial roles of TREM2 macrophages and fibroblasts in tumor microenvironments.

Applications

Unspecified application

Species

Unspecified reactive species

Qianqian Cao,Dianshui Sun,Can Tu,Jihua Wang,Runjia Fu,Rumei Gong,Yueying Xiao,Qin Liu,Xiaomei Li

Journal of developmental biology 10: PubMed35893125

2022

Acetaminophen Disrupts the Development of Pharyngeal Arch-Derived Cartilage and Muscle in Zebrafish.

Applications

Unspecified application

Species

Unspecified reactive species

Derrick M Glasco,Zhidong Wang,Seonwoo Kang,Avery T Funkhouser
View all publications
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