JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB167605

Anti-SP100 antibody

5

(1 Review)

|

(5 Publications)

Mouse Polyclonal SP100 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Nuclear autoantigen Sp-100.

View Alternative Names

Nuclear autoantigen Sp-100, Nuclear dot-associated Sp100 protein, Speckled 100 kDa, SP100

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SP100 antibody (AB167605)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SP100 antibody (AB167605)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spleen tissue labeling SP100 with ab167605 at 3 μg/ml.

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Nuclear autoantigen Sp-100.

P23497

style
left-column

Complementary Products

Primary Antibodies

AB179466

Anti-PML Protein antibody [EPR16792]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-PML Protein antibody [EPR16792] (AB179466)

  • 5
  • 5
Primary Antibodies

AB1791

Anti-Histone H3 antibody - Nuclear Marker and ChIP Grade

Lab Essentials

ChIP - Anti-Histone H3 antibody - Nuclear Marker and ChIP Grade (AB1791)

  • 5
  • 233
Primary Antibodies

AB32058

Anti-Sumo 1 antibody [Y299] - ChIP Grade

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sumo 1 antibody [Y299] - ChIP Grade (AB32058)

  • 4
  • 11
Primary Antibodies

AB9050

Anti-Histone H3 (tri methyl K36) antibody - ChIP Grade

ChIP - Anti-Histone H3 (tri methyl K36) antibody - ChIP Grade (AB9050)

  • 5
  • 64
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p>Isoform A predicted MW 54 kDa.</p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3 µg/mL", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
style
left-column
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed : 11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed : 15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.
See full target information Nuclear autoantigen Sp-100
style
left-column

Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Cell proliferation 57:e13566 PubMed37864298

2023

PML-mediated nuclear loosening permits immunomodulation of mesenchymal stem/stromal cells under inflammatory conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Yunpeng Chu,Zishan Jiang,Zheng Gong,Xiaocao Ji,Mengting Zhu,Qianwen Shang,Pixia Gong,Lijuan Cao,Yongjing Chen,Peishan Li,Changshun Shao,Yufang Shi

Nature structural & molecular biology 29:922-931 PubMed36097294

2022

Smc5/6 silences episomal transcription by a three-step function.

Applications

Unspecified application

Species

Unspecified reactive species

Fabien Abdul,Aurélie Diman,Bastien Baechler,Dhivya Ramakrishnan,Dmytro Kornyeyev,Rudolf K Beran,Simon P Fletcher,Michel Strubin

BMC biology 20:182 PubMed35986286

2022

Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140.

Applications

Unspecified application

Species

Unspecified reactive species

Mohammed Ghiboub,Jan Koster,Peter D Craggs,Andrew Y F Li Yim,Anthony Shillings,Sue Hutchinson,Ryan P Bingham,Kelly Gatfield,Ishtu L Hageman,Gang Yao,Heather P O'Keefe,Aaron Coffin,Amish Patel,Lisa A Sloan,Darren J Mitchell,Thomas G Hayhow,Laurent Lunven,Robert J Watson,Christopher E Blunt,Lee A Harrison,Gordon Bruton,Umesh Kumar,Natalie Hamer,John R Spaull,Danny A Zwijnenburg,Olaf Welting,Theodorus B M Hakvoort,Anje A Te Velde,Johan van Limbergen,Peter Henneman,Rab K Prinjha,Menno P J de Winther,Nicola R Harker,David F Tough,Wouter J de Jonge

Molecular cell 81:1027-1042.e4 PubMed33453166

2021

Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies.

Applications

Unspecified application

Species

Unspecified reactive species

Jia-Min Zhang,Marie-Michelle Genois,Jian Ouyang,Li Lan,Lee Zou

PLoS pathogens 13:e1006542 PubMed28750047

2017

Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase.

Applications

Unspecified application

Species

Unspecified reactive species

Xi-Juan Liu,Bo Yang,Sheng-Nan Huang,Cong-Cong Wu,Xiao-Jun Li,Shuang Cheng,Xuan Jiang,Fei Hu,Ying-Zi Ming,Michael Nevels,William J Britt,Simon Rayner,Qiyi Tang,Wen-Bo Zeng,Fei Zhao,Min-Hua Luo
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com