Anti-Sp5 antibody [EPR11367(2)]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Sp5 also known as SAM Pointed Domain Containing ETS Transcription Factor is a transcription factor involved in various cellular processes. It has a mass of approximately 44 kDa and is expressed in several tissues including the brain kidney and liver. Sp5 functions by binding to GC-rich motifs in DNA where it regulates gene expression. Its activity influences the transcription of target genes that are critical for developmental and cellular responses.

Biological function summary

Sp5 plays an essential role in development and cell proliferation. It does not typically form part of a larger protein complex but works on its own to modulate the expression of genes linked to the Wnt signaling pathway. In the context of embryonic development Sp5 ensures proper cell specification and tissue patterning. Dysregulation of Sp5 activity can therefore have widespread effects on organismal biology affecting multiple systems and processes.

Pathways

Sp5 participates actively in the Wnt/β-catenin signaling pathway. This pathway is critical for cellular homeostasis and embryogenesis. Sp5 works together with other proteins like TCF/LEF transcription factors to mediate Wnt target gene activation. Its regulation is critical for maintaining the balance of cellular activities impacting processes such as stem cell differentiation and self-renewal. Furthermore Sp5 has interactions with the Hedgehog signaling pathway which further connects its role in controlling cellular growth and differentiation.

Associated diseases and disorders

Sp5 is linked to colorectal cancer and developmental disorders. These conditions arise partly due to its regulatory roles in the Wnt/β-catenin pathway. Altered expression of Sp5 can lead to inappropriate activation of genes involved in cell cycle progression and can contribute to cancer tumorigenesis. In colorectal cancer Sp5 often shows upregulated expression potentially influencing tumor progression. Its interaction with proteins like β-catenin highlights its contribution to pathway disruptions that promote disease states.