Rabbit Polyclonal SPATA6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SPATA6.
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Publications
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- Biology of reproduction 100:561-5722018Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2†.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYue He,Yu Lin,Yu Zhu,Ping Ping,Guishuan Wang,Fei SunPubMed 30295753
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human SPATA6. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NWH7
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Rat | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/200.00000 - 1/1000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/25.00000 - 1/100.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Target data
Function
Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits.
Alternative names
Spermatogenesis-associated protein 6, SPATA6
Recommended products
Rabbit Polyclonal SPATA6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SPATA6.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human SPATA6. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NWH7
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SPATA6 also known as Spermatogenesis Associated 6 is a protein involved in the mechanical processes of cell development. The protein has a mass of around 62 kDa. SPATA6 expression primarily occurs in the testis suggesting a role in reproductive biology. It facilitates the proper function and structure of microtubules which are important in maintaining cell shape and division. As a part of the spermatogenic process SPATA6 contributes to the complex progression of sperm maturation making proper sperm function reliant on its activity.
- Biological function summary
SPATA6 plays an important role in spermatogenesis the process where sperm cells form. The protein contributes to spermatid elongation and acrosome development. It possibly exists within a larger complex associated with microtubule proteins that support cell movement and stability. This association enables SPATA6 to influence the integrity and motility of spermatozoa. By interacting with cytoskeletal components SPATA6 aids in the structural reorganization necessary for productive reproduction.
- Pathways
SPATA6 interacts within the reproductive pathways that govern sperm development and function. It associates with pathways involved in cytoskeletal rearrangements specifically implicating it in microtubule-organizing structures. SPATA6 indirectly links to proteins such as kinesin family members that regulate molecular motor activities playing a part in efficient intracellular transport and cellular morphology. These pathways ensure the coordination of structural transformations essential during germ cell maturation.
- Associated diseases and disorders
SPATA6 mutations or malfunctions relate to reproductive disorders particularly male infertility. Disruption in SPATA6 may lead to compromised sperm motility impacting fertilization ability. The improper function of SPATA6 can result in defective spermatid development showing potential correlations with proteins involved in cytoskeletal configurations like tubulins. A deeper understanding of SPATA6 interactions could provide insight into therapeutic targets for treating infertility and other reproductive health issues.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SPATA6 antibody (ab197680)
Immunohistochemical analysis of formalin fixed paraffin embedded human liver cancer tissue labeling SPATA6 with ab197680 at a 1/40 dilution.
Western blot - Anti-SPATA6 antibody (ab197680)
8% SDS PAGE gel
All lanes: Western blot - Anti-SPATA6 antibody (ab197680) at 1/1000 dilution
All lanes: human testis tissue lysate at 60 µg
Predicted band size: 56 kDa
Exposure time: 5min
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