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AB111223

Anti-Spectrin beta 5 antibody

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(2 Publications)

Rabbit Polyclonal Sptbn5 antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 2 publications.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB, IHC-P

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Spectrin beta 5 also known as SPTBN5 or SPFH2 is a part of the spectrin family of proteins. It functions as a cytoskeletal protein that contributes to stabilizing cellular structures. This protein has a mass of about 280 kDa and plays a significant role in maintaining the structural integrity of the plasma membrane. Spectrin beta 5 is expressed in a variety of tissues but it is known for its presence in the brain where it is involved in supporting neuronal organization.
Biological function summary

Spectrin beta 5 helps organize the cytoskeletal matrix by linking actin filaments creating a network that supports cellular architecture. It does not act alone but rather as part of the spectrin-actin complex. This complex is essential for sustaining the elasticity and durability of the membrane contributing to processes like cell shape maintenance and signal transduction. Its association with microtubules further extends its role in intracellular transport and mechanical stability.

Pathways

This protein integrates with cellular pathways that manage the structural dynamics of cells. Spectrin beta 5 participates in pathways related to cytoskeleton reorganization and membrane stabilization. Within these pathways it interacts with proteins like ankyrin and actin facilitating their roles in cellular resilience and integrity. It significantly impacts the spectrin/ankyrin pathway which is critical for anchoring membrane proteins to the cytoskeleton.

Spectrin beta 5 has been associated with neurological disorders where its function or expression may be disrupted. Malfunctions in its cytoskeletal role can contribute to conditions like neurodegenerative diseases and epilepsy. This protein is connected to other spectrin family proteins such as spectrin alpha which are involved in similar disease pathways due to shared functions in maintaining neuronal stability and communication.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Sptbn5
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 28:e18541 PubMed39046429

2024

Novel candidate metastasis-associated genes for synovial sarcoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiqing Zhao,Jianfang Niu,Jichuan Wang,Ranxin Zhang,Haijie Liang,Yingteng Ma,Alexander Ferrena,Wei Wang,Rui Yang,David S Geller,Wei Guo,Tingting Ren,Bang H Hoang,Xiaodong Tang,Taiqiang Yan

Cytoskeleton (Hoboken, N.J.) 72:157-70 PubMed25903931

2015

Spectrin alpha is important for rear polarization of the microtubule organizing center during migration and spindle pole assembly during division of neointimal smooth muscle cells.

Applications

Unspecified application

Species

Unspecified reactive species

Rosalind V Silverman-Gavrila,Lorelei B Silverman-Gavrila,Khawaja Hasan Bilal,Michelle P Bendeck
View all publications
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