Anti-SPIN90 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SPIN90 also known as SH3 protein interacting with NCK with a molecular mass of approximately 90 kDa acts as a scaffold protein involved in the regulation of actin dynamics. SPIN90 belongs to a group of proteins known for their role in organizing protein complexes at actin filament sites. It facilitates the connection between the actin cytoskeleton and various signaling pathways. This protein shows expression mainly in the brain but is present in other tissues as well.

Biological function summary

Proteins such as SPIN90 help regulate the reorganization of the actin cytoskeleton important for cell movement and cytoskeletal integrity. It forms part of a larger complex that includes proteins like N-WASP and Arp2/3 complex. These interactions suggest that SPIN90 is an important player in actin polymerization and branching influencing cellular processes like migration endocytosis and morphogenesis.

Pathways

SPIN90 functions centrally in signaling pathways like the Rho GTPase signaling and epidermal growth factor receptor (EGFR) pathways. In these pathways SPIN90 interacts closely with proteins such as Cdc42 and Rac1 which are critical for controlling cell shape and promoting the formation of signal transduction complexes. This integration highlights the protein's influence in maintaining cell structure and promoting cell signaling responsiveness.

Associated diseases and disorders

SPIN90 has associations with neurodegenerative disorders and cancer progression. Its interaction with proteins like Aβ and tau in the central nervous system suggests a role in Alzheimer's disease where cytoskeletal disruptions are a pathology hallmark. Furthermore SPIN90's relationship with proteins such as Src in cancer highlights its potential involvement in tumor cell motility and metastasis offering insights into mechanisms that drive these diseases.