JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB121890

Anti-SPINK2 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal SPINK2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SPINK2 aa 1 to C-terminus.

View Alternative Names

Serine protease inhibitor Kazal-type 2, Acrosin-trypsin inhibitor, Epididymis tissue protein Li 172, HUSI-II, SPINK2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SPINK2 antibody (AB121890)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SPINK2 antibody (AB121890)

ab121890 at 1/500 dilution staining SPINK2 in Paraffin-embedded Human testis tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SPINK2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P20155

style
left-column

Complementary Products

Proteins & Peptides

AB276569

Recombinant Human SPINK2 protein (Fc Chimera)

SDS-PAGE - Recombinant Human SPINK2 protein (Fc Chimera) (AB276569)

  • 0
  • 0
Primary Antibodies

AB118800

Anti-ZZZ3 antibody

Immunoprecipitation - Anti-ZZZ3 antibody (AB118800)

  • 0
  • 0
Primary Antibodies

AB121685

Anti-ZNF750 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZNF750 antibody (AB121685)

  • 0
  • 0
Primary Antibodies

AB117837

Anti-ZNF787 antibody

Immunoprecipitation - Anti-ZNF787 antibody (AB117837)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SPINK2 also known as Serine Protease Inhibitor Kazal-type 2 functions mechanically as a serine protease inhibitor that regulates proteolytic processes. The molecular mass of SPINK2 is approximately 8.5 kDa. It has expression in a variety of tissues most prominently in the testes but also in other organs such as the ovary and kidney. SPINK2 has a role in the defense against protease enzyme reactions that can lead to tissue damage by inhibiting proteolytic activities.
Biological function summary

SPINK2 plays an important role in maintaining tissue integrity by restricting excessive protease activity. This can be critical in tissues that undergo regular structural changes. SPINK2 does not associate with a particular complex but impacts several biological processes by modulating the activity of enzymes it inhibits. This function highlights its role in cellular protection and maintenance especially within reproductive tissues where dynamic protein degradation and synthesis are consistent.

Pathways

This protease inhibitor takes part in essential regulatory pathways such as the coagulation cascade and the management of protease activity in various tissues. Its activity influences pathways involving serine proteases such as the kallikrein system. Directly related proteins through these pathways include proteases like kallikreins which SPINK2 inhibits to modulate physiologic balance within the reproductive and other organ systems.

SPINK2 has links to conditions such as male infertility where abnormal protease activity can disrupt normal spermatogenesis. It also associates with certain cancer types like testicular cancer where protease regulation goes awry. In these contexts SPINK2 interacts with other proteins like the cancer-promoting oncoproteins and proteases that drive tumor progression and metastasis indicating a potential avenue for therapeutic interventions targeting abnormal SPINK2 function.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed : 28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin.
See full target information SPINK2
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of periodontal research 58:800-812 PubMed37221903

2023

ScRNA-seq links dental fibroblasts heterogeneity with mechanoresponsiveness.

Applications

Unspecified application

Species

Unspecified reactive species

Hongyuan Xu,Qinggang Dai,Xinyu Wang,Anting Jin,Yiling Yang,Xiangru Huang,Xijun Wang,Xin Gao,Siyuan Sun,Yuanqi Liu,Yanfei Zhu,Steve Gf Shen,Qian Bian,Lingyong Jiang
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com