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AB201319

Anti-SPINK6 antibody

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(2 Publications)

Rabbit Polyclonal SPINK6 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SPINK6 aa 1 to C-terminus.

View Alternative Names

UNQ844/PRO1782, SPINK6, Serine protease inhibitor Kazal-type 6, Kallikrein inhibitor

1 Images
Western blot - Anti-SPINK6 antibody (AB201319)
  • WB

Supplier Data

Western blot - Anti-SPINK6 antibody (AB201319)

All lanes:

Western blot - Anti-SPINK6 antibody (ab201319)

Lane 1:

Raw264.7 whole cell lysate

Lane 2:

H9C2 whole cell lysate

Lane 3:

HeLa whole cell lysate

Predicted band size: 9 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human SPINK6 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6UWN8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purity is > 95% (by SDS-PAGE).
Storage buffer
pH: 7.3 Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SPINK6 also known as Serine Peptidase Inhibitor Kazal Type 6 is a small protein with a mass of about 9.4 kDa. It acts mechanically as a serine protease inhibitor blocking the activity of certain enzymes that cleave peptide bonds in proteins. SPINK6 expresses mainly in the skin and in some epithelial tissues where it regulates proteolytic activity. This regulation plays an important role in maintaining tissue homeostasis and protecting against excessive protease activity that could damage cells.
Biological function summary

Serine protease inhibitory actions of SPINK6 contribute significantly to skin barrier function and immune defense. While SPINK6 is not currently known to be part of a larger protein complex its inhibitory effects on enzymes like trypsin and kallikreins implicate it in processes that control skin desquamation and inflammation. These processes ensure proper shedding of skin and protection against microbial invasion illustrating SPINK6's protective role in epithelial surfaces.

Pathways

Specific functions of SPINK6 link it to the regulation of the kallikrein-kinin system and inflammation pathways. Through inhibitory interactions SPINK6 modulates the activity of proteins like KLK5 and KLK7 important in skin physiology. These interactions help maintain balance in the epidermal environment by controlling protease activity that could otherwise activate inflammatory cascades or impair barrier function.

In terms of diseases and disorders closely connected to SPINK6 disruptions in its expression or function may relate to skin conditions like atopic dermatitis and psoriasis. Such disorders can result from imbalances in protease inhibition leading to excessive inflammation and barrier dysfunction. KLK5 in particular has strong links to these conditions as alterations in the regulation by SPINK6 can exacerbate disease severity by increasing inflammation and skin barrier permeability.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.
See full target information SPINK6
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular physiology 239:e31251 PubMed38634445

2024

KLF13 promotes VSMCs phenotypic dedifferentiation by directly binding to the SM22α promoter.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaofan Yuan,Chuan Jiang,Yuzhou Xue,Fuqiang Guo,Minghao Luo,Lei Guo,Yang Gao,Tongling Yuan,Hui Xu,Hong Chen

EMBO molecular medicine 14:e14485 PubMed34826211

2021

SPINK6 inhibits human airway serine proteases and restricts influenza virus activation.

Applications

Unspecified application

Species

Unspecified reactive species

Dong Wang,Cun Li,Man Chun Chiu,Yifei Yu,Xiaojuan Liu,Xiaoyu Zhao,Jingjing Huang,Zhongshan Cheng,Shuofeng Yuan,Vincent Poon,Jian-Piao Cai,Hin Chu,Jasper Fuk-Woo Chan,Kelvin Kai-Wang To,Kwok Yung Yuen,Jie Zhou
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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