AB247061

Anti-SPP antibody

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(6 Publications)

Rabbit Polyclonal SPP antibody. Suitable for IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HM13 aa 100-250.

View Alternative Names

H13, IMP1, PSL3, SPP, MSTP086, HM13, Minor histocompatibility antigen H13, Intramembrane protease 1, Presenilin-like protein 3, Signal peptide peptidase, IMP-1, IMPAS-1, hIMP1

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SPP antibody (AB247061)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SPP antibody (AB247061)

Paraffin-embedded human pancreas tissue stained for SPP using ab247061 at 1/200 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human HM13 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

Q8TCT9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed : 11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed : 12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed : 11714810, PubMed : 12077416, PubMed : 14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed : 25239945). May play a role in graft rejection (By similarity).

See full target information HM13

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Histology and histopathology 40:1435-1446 PubMed39703990

2024

HM13 is a predictive biomarker of metastasis and neutrophil infiltration in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yanbing Ren,Ying Mao,Xiao Yuan

Communications biology 7:177 PubMed38418614

2024

Modular tissue-in-a-CUBE platform to model blood-brain barrier (BBB) and brain interaction.

Applications

Unspecified application

Species

Unspecified reactive species

Isabel Koh,Masaya Hagiwara

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 38:e23390 PubMed38169064

2024

Single-cell RNA sequencing reveals the heterogeneity of epithelial cell and fibroblast cells from non- to metastatic lymph node OTSCC.

Applications

Unspecified application

Species

Unspecified reactive species

Dandan Song,Fei Yang,Yang Sun,Xingwen Wu,Qianrong Zhou,Wei Bi,Jian Sun,Siyi Li,Youcheng Yu

Molecular cell 82:4277-4289.e10 PubMed36283413

2022

ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Michael J McKenna,Benjamin M Adams,Vincent Chu,Joao A Paulo,Sichen Shao

BMC cancer 22:888 PubMed35964022

2022

Identification of HM13 as a prognostic indicator and a predictive biomarker for immunotherapy in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Genhao Zhang,Xianping Lv,Qiankun Yang,Hongchun Liu

Journal for immunotherapy of cancer 9: PubMed34663641

2021

Targeting human leukocyte antigen G with chimeric antigen receptors of natural killer cells convert immunosuppression to ablate solid tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Chia-Ing Jan,Shi-Wei Huang,Peter Canoll,Jeffrey N Bruce,Yu-Chuan Lin,Chih-Ming Pan,Hsin-Man Lu,Shao-Chih Chiu,Der-Yang Cho

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SPP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SPP antibody (AB247061)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (6)

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