Mouse Polyclonal SREBP2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SREBF2 aa 800-900.
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Publications
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- Signal transduction and targeted therapy 5:1862020COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWonhwa Lee et. al.PubMed 32883951
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
Constituents: 50% Glycerol (glycerin, glycerine)
- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human SREBF2 aa 800-900. The exact immunogen used to generate this antibody is proprietary information. Database link Q12772
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes - |
Associated Products
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2 products for Alternative Product
Target data
Function
Sterol regulatory element-binding protein 2. Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). Processed sterol regulatory element-binding protein 2. Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062).
Alternative names
BHLHD2, SREBP2, SREBF2, Sterol regulatory element-binding protein 2, SREBP-2, Class D basic helix-loop-helix protein 2, Sterol regulatory element-binding transcription factor 2, bHLHd2
Recommended products
Mouse Polyclonal SREBP2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SREBF2 aa 800-900.
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
Constituents: 50% Glycerol (glycerin, glycerine)
- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human SREBF2 aa 800-900. The exact immunogen used to generate this antibody is proprietary information. Database link Q12772
- Purity
- Whole antiserum
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-SREBP2 antibody (ab194667)
All lanes: Western blot - Anti-SREBP2 antibody (ab194667) at 1/500 dilution
All lanes: IMR-32 cell lysate at 50 µg
Developed using the ECL technique.
Predicted band size: 123 kDa
Western blot - Anti-SREBP2 antibody (ab194667)
Predicted MWt of immunogen: 37.0 kDa.
All lanes: Western blot - Anti-SREBP2 antibody (ab194667) at 1/1000 dilution
All lanes: Recombinant Human SREBP2 protein (immunogen) at 0.2 µg
Developed using the ECL technique.
Predicted band size: 123 kDa
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