AB194667

Anti-SREBP2 antibody

Name: Anti-SREBP2 antibody (ab194667) | Abcam
Brand: Abcam Limited
SKU: AB194667
Price: 535 USD
Availability: InStock

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(3 Publications)

Mouse Polyclonal SREBP2 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SREBF2 aa 800-900.

View Alternative Names

BHLHD2, SREBP2, SREBF2, Sterol regulatory element-binding protein 2, SREBP-2, Class D basic helix-loop-helix protein 2, Sterol regulatory element-binding transcription factor 2, bHLHd2

2 Images

Supplier Data

Western blot - Anti-SREBP2 antibody (AB194667)

All lanes:

Western blot - Anti-SREBP2 antibody (ab194667) at 1/500 dilution

All lanes:

IMR-32 cell lysate at 50 µg

Predicted band size: 123 kDa

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Supplier Data

Western blot - Anti-SREBP2 antibody (AB194667)

Predicted MWt of immunogen : 37.0 kDa.

All lanes:

Western blot - Anti-SREBP2 antibody (ab194667) at 1/1000 dilution

All lanes:

Recombinant Human SREBP2 protein (immunogen) at 0.2 µg

Predicted band size: 123 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human SREBF2 aa 800-900. The exact immunogen used to generate this antibody is proprietary information.

Q12772

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purity

Whole antiserum

Storage buffer

Constituents: 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Sterol regulatory element-binding protein 2. Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed : 32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed : 32322062).. Processed sterol regulatory element-binding protein 2. Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed : 12177166, PubMed : 32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed : 12177166, PubMed : 7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed : 12177166, PubMed : 32322062).

See full target information SREBF2

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:15696 PubMed40325086

2025

Kratom leaf extracts exert hypolipidaemic effects via the modulation of PCSK9 and LDLR pathways in HepG2 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Nantiya Nawaka,Monthon Lertcanawanichakul,Sureerut Porntadavity,Burabha Pussadhamma,Nutjaree Jeenduang

Signal transduction and targeted therapy 5:186 PubMed32883951

2020

COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm.

Applications

Unspecified application

Species

Unspecified reactive species

Wonhwa Lee,June Hong Ahn,Hee Ho Park,Hong Nam Kim,Hyelim Kim,Youngbum Yoo,Hyosoo Shin,Kyung Soo Hong,Jong Geol Jang,Chun Gwon Park,Eun Young Choi,Jong-Sup Bae,Young-Kyo Seo

Molecular medicine reports 18:2561-2570 PubMed30015916

2018

Aucubin suppresses Titanium particles‑mediated apoptosis of MC3T3‑E1 cells and facilitates osteogenesis by affecting the BMP2/Smads/RunX2 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ziguan Zhu,Qingping Xie,Yazeng Huang,Shuijun Zhang,Yu Chen

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-SREBP2 antibody

Western blot - Anti-SREBP2 antibody (AB194667)

Western blot - Anti-SREBP2 antibody (AB194667)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (3)

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