JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB222799

Anti-SRGAP2C antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal SRGAP2C antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SRGAP2C aa 1-250.

View Alternative Names

SRGAP2P1, SRGAP2C, SLIT-ROBO Rho GTPase-activating protein 2C, SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-SRGAP2C antibody (AB222799)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SRGAP2C antibody (AB222799)

A549 (human lung carcinoma cell line) cells stained for SRGAP2C (green) using ab222799 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488-congugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SRGAP2C antibody (AB222799)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SRGAP2C antibody (AB222799)

Paraffin-embedded human colon cancer tissue stained for SRGAP2C with ab222799 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SRGAP2C aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

P0DJJ0

style
left-column

Complementary Products

Primary Antibodies

AB174314

Anti-PAPP A antibody [EPR12897]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PAPP A antibody [EPR12897] (AB174314)

  • 0
  • 0
Primary Antibodies

AB174304

Anti-MKLP1 antibody [EPR10879]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-MKLP1 antibody [EPR10879] (AB174304)

  • 0
  • 0
Primary Antibodies

AB110383

Anti-ZnT1 antibody

Western blot - Anti-ZnT1 antibody (AB110383)

  • 0
  • 0
Assay Kits

AB234574

Human CXCL3 ELISA Kit

Recombinant|SimpleStep

ELISA - Human CXCL3 ELISA Kit (AB234574)

  • 5
  • 1
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Human-specific protein that acts as a key modifier of cortical connectivity in the human brain (PubMed : 22559944, PubMed : 27373832, PubMed : 34707291). Acts by inhibiting the functions of ancestral paralog SRGAP2/SRGAP2A, a postsynaptic protein that regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed : 22559944, PubMed : 27373832). SRGAP2C is unstable but is able to heterodimerize with SRGAP2/SRGAP2A, thereby reducing SRGAP2/SRGAP2A levels through proteasome-dependent degradation (PubMed : 27373832, PubMed : 28333212, PubMed : 31822692). Inhibition of SRGAP2/SRGAP2A by SRGAP2C leads to an increase in synaptic density and protracted synaptic maturation of both excitatory and inhibitory synapses (PubMed : 27373832, PubMed : 34707291). Modifies cortical circuit connectivity by increasing the number of local and long-range cortical inputs received by layer 2/3 pyramidal neurons (PubMed : 34707291). Also able to increase the probability of sensory-evoked responses by layer 2/3 pyramidal neurons (PubMed : 34707291).
See full target information SRGAP2C
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 8:582220 PubMed33163494

2020

Protein Tyrosine Phosphatase Receptor S Acts as a Metastatic Suppressor in Malignant Peripheral Nerve Sheath Tumor via Profilin 1-Induced Epithelial-Mesenchymal Transition.

Applications

Unspecified application

Species

Unspecified reactive species

Jie-Yi Ren,Yi-Hui Gu,Xi-Wei Cui,Man-Mei Long,Wei Wang,Cheng-Jiang Wei,Bin Gu,Hai-Bing Zhang,Qing-Feng Li,Zhi-Chao Wang
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com