Rabbit Polyclonal SRSF3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human SRSF3.
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Publications
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- Development (Cambridge, England) 148:2021Srsf3 mediates alternative RNA splicing downstream of PDGFRα signaling in the facial mesenchyme.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBrenna J C Dennison,Eric D Larson,Rui Fu,Julia Mo,Katherine A FantauzzoPubMed 34184034
- Brain : a journal of neurology 143:3273-32932020Splicing machinery dysregulation drives glioblastoma development/aggressiveness: oncogenic role of SRSF3.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAntonio C Fuentes-Fayos,Mari C Vázquez-Borrego,Juan M Jiménez-Vacas,Leire Bejarano,Sergio Pedraza-Arévalo,Fernando L-López,Cristóbal Blanco-Acevedo,Rafael Sánchez-Sánchez,Oscar Reyes,Sebastián Ventura,Juan Solivera,Joshua J Breunig,María A Blasco,Manuel D Gahete,Justo P Castaño,Raúl M LuquePubMed 33141183
- Cancer discovery 10:1388-14092020Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYalu Zhou,Cuijuan Han,Eric Wang,Adam H Lorch,Valentina Serafin,Byoung-Kyu Cho,Blanca T Gutierrez Diaz,Julien Calvo,Celestia Fang,Alireza Khodadadi-Jamayran,Tommaso Tabaglio,Christian Marier,Anna Kuchmiy,Limin Sun,George Yacu,Szymon K Filip,Qi Jin,Yoh-Hei Takahashi,David R Amici,Emily J Rendleman,Radhika Rawat,Silvia Bresolin,Maddalena Paganin,Cheng Zhang,Hu Li,Irawati Kandela,Yuliya Politanska,Hiam Abdala-Valencia,Marc L Mendillo,Ping Zhu,Bruno Palhais,Pieter Van Vlierberghe,Tom Taghon,Iannis Aifantis,Young Ah Goo,Ernesto Guccione,Adriana Heguy,Aristotelis Tsirigos,Keng Boon Wee,Rama K Mishra,Francoise Pflumio,Benedetta Accordi,Giuseppe Basso,Panagiotis NtziachristosPubMed 32444465
- The Journal of clinical investigation 129:4477-44912019Degradation of splicing factor SRSF3 contributes to progressive liver disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDeepak Kumar et. al.PubMed 31393851
- eLife 6:2017YTHDC1 mediates nuclear export of N-methyladenosine methylated mRNAs.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIan A Roundtree et. al.PubMed 28984244
- International journal of oncology 51:169-1832017Fyn/heterogeneous nuclear ribonucleoprotein E1 signaling regulates pancreatic cancer metastasis by affecting the alternative splicing of integrin β1.
- American journal of physiology. Cell physiology 308:C289-962014TRA2β controls Mypt1 exon 24 splicing in the developmental maturation of mouse mesenteric artery smooth muscle.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaoxu Zheng,John J Reho,Brunhilde Wirth,Steven A FisherPubMed 25428883
- Molecular and cellular biology 34:1747-562014Homer1 alternative splicing is regulated by gonadotropin-releasing hormone and modulates gonadotropin gene expression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQian Wang et. al.PubMed 24591653
- Nature communications 4:13362013Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human SRSF3. The exact immunogen used to generate this antibody is proprietary information. Database link P84103
Consider this alternative
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/1000 | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/1000 | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).
Alternative names
SFRS3, SRP20, SRSF3, Serine/arginine-rich splicing factor 3, Pre-mRNA-splicing factor SRP20
Recommended products
Rabbit Polyclonal SRSF3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human SRSF3.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human SRSF3. The exact immunogen used to generate this antibody is proprietary information. Database link P84103
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-SRSF3 antibody (ab73891)
All lanes: Western blot - Anti-SRSF3 antibody (ab73891) at 1/500 dilution
Lane 1: extracts from HeLa cells at 30 µg
Lane 2: extracts from Jurkat cells at 30 µg
Lane 3: extracts from Jurkat cells at 30 µg with immunizing peptide
Predicted band size: 19 kDa
Observed band size: 19 kDa
Immunocytochemistry/ Immunofluorescence - Anti-SRSF3 antibody (ab73891)
Left panel: immunofluorescence analysis of MCF7 cells, using 1/500-1/1000 ab73891; Right panel: same, after pre-incubation with the immunizing peptide.
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