AB193174
Anti-SRY/TDF antibody - N-terminal
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Rabbit Polyclonal SRY/TDF antibody. N-terminal. Suitable for WB and reacts with Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Mouse Sry aa 1-150.
View Alternative Names
Tdf, Tdy, Sry, Sex-determining region Y protein, Testis-determining factor
Reactivity data
{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
Properties and storage information
Form
Liquid
Purification technique
Precipitation Caprylic Acid and Ammonium Sulphate
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
Product protocols
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Target data
Transcriptional regulator that controls a genetic switch in male development (PubMed : 33004521). It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (PubMed : 33004521). Involved in different aspects of gene regulation including promoter activation or repression (PubMed : 15170344, PubMed : 8159753, PubMed : 8190643). Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (PubMed : 15170344, PubMed : 8159753, PubMed : 8190643). SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending (PubMed : 15170344, PubMed : 8159753, PubMed : 8190643). Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).. Isoform Sry-T. Constitutes the major isoform, which is necessary and sufficient for initiating male sex determination.. Isoform Sry-S. Constitutes a minor isoform, which is unstable due to the presence of a degron at the C-terminus that promotes its degradation (PubMed : 33004521). Not necessary and sufficient for initiating male sex determination (PubMed : 33004521).
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Associated Products
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Alternative Product
Primary Antibodies
AB140309
Anti-SRY/TDF antibody [OTI3C8]
primary-antibodies
sry-tdf-antibody-oti3c8-ab140309
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