Mouse Polyclonal SSX4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SSX4.
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Publications
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- Oncotarget 7:49677-496872016The "melanoma-enriched" microRNA miR-4731-5p acts as a tumour suppressor.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMitchell S Stark,Lisa N Tom,Glen M Boyle,Vanessa F Bonazzi,H Peter Soyer,Adrian C Herington,Pamela M Pollock,Nicholas K HaywardPubMed 27331623
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human SSX4. Database link O60224
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1 µg/mL | Notes - |
Alternative names
SSX4A, SSX4B, SSX4, Protein SSX4, Cancer/testis antigen 5.4, CT5.4
Recommended products
Mouse Polyclonal SSX4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SSX4.
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human SSX4. Database link O60224
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SSX4 also known as Synovial Sarcoma X breakpoint 4 is a protein belonging to the SSX family of proteins. This protein has a molecular weight of approximately 22 kDa. It is typically expressed in testicular tissues but also appears in various tumors. Like other SSX proteins SSX4 contains a characteristic KRAB domain suggesting its involvement in transcriptional regulation processes.
- Biological function summary
The function of SSX4 extends to the regulation of transcription. It may act as a transcriptional repressor and participate in chromatin remodeling. SSX4 can form part of larger protein complexes influencing transcriptional activity in the cells where it is expressed. In cancer cells this protein's transcriptional regulatory role might contribute to abnormal cell growth through altered gene expression patterns.
- Pathways
The SSX4 protein interacts within cellular pathways associated with tumorigenesis and transcriptional regulation. It is connected to the MAPK signaling pathway impacting cellular proliferation and survival. SSX4 may have interactions with proteins in the MAPK pathway such as RAF and ERK which mediate signal transduction processes involved in cell growth and differentiation.
- Associated diseases and disorders
The abnormal expression of SSX4 is linked primarily to synovial sarcoma a type of soft tissue cancer. SSX4 when involved in translocations can create fusion proteins like SSX4-SS18 that alter normal cellular pathways leading to tumorigenesis. This protein is also investigated in contexts of other cancers potentially interacting with proteins like SSX2 through shared pathway mechanisms in cancerous growth.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-SSX4 antibody (ab172215)
All lanes: Western blot - Anti-SSX4 antibody (ab172215) at 1 µg/mL
Lane 1: SSX4 transfected 293T cell lysate at 15 µL
Lane 2: Non-transfected 293T cell lysate at 15 µL
SecondaryAll lanes: Goat Anti-Mouse IgG at 1/2500 dilution
Predicted band size: 22 kDa
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