Rabbit Polyclonal ST3GAL2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ST3GAL2 aa 1-200.
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- Science advances 9:eadg26152023Human-specific features and developmental dynamics of the brain N-glycome.Applications:Unspecified applicationReactive species:Unspecified reactive speciesThomas S Klarić,Ivan Gudelj,Gabriel Santpere,Mislav Novokmet,Frano Vučković,Shaojie Ma,Hannah M Doll,Ryan Risgaard,Shveta Bathla,Amir Karger,Angus C Nairn,Victor Luria,Ivona Bečeheli,Chet C Sherwood,John J Ely,Patrick R Hof,André M M Sousa,Djuro Josić,Gordan Lauc,Nenad SestanPubMed 38055821
- American journal of cancer research 12:280-3022022knock-down decreases tumoral character of colorectal cancer cells and .Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarlène Deschuyter,David Yannick Leger,Anne Verboom,Alain Chaunavel,Abderrahman Maftah,Jean-Michel PetitPubMed 35141018
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human ST3GAL2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q16842
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Chimpanzee | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Chimpanzee | Dilution info - | Notes - |
Associated Products
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Target data
Function
A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8920913, PubMed:9266697). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:25916169, PubMed:8920913, PubMed:9266697). Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8920913, PubMed:9266697). Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity). Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (By similarity). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (PubMed:12716912). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:25916169, PubMed:9266697).
Alternative names
SIAT4B, ST3GAL2, Gal-NAc6S, Monosialoganglioside sialyltransferase, ST3Gal II, ST3GalA.2, Sialyltransferase 4B, ST3GalII, SIAT4-B
Recommended products
Rabbit Polyclonal ST3GAL2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ST3GAL2 aa 1-200.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human ST3GAL2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q16842
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ST3GAL2 also known as ST3 beta-galactoside alpha-23-sialyltransferase 2 is an enzyme encoded by the ST3GAL2 gene. It is involved in the transfer of sialic acid onto galactose-containing oligosaccharides. The protein has a molecular mass of approximately 38 kDa. ST3GAL2 is expressed in a variety of tissues with higher expression reported in the brain and placenta. It localizes mainly to the Golgi apparatus where it participates in the modification of glycoproteins and glycolipids.
- Biological function summary
The enzyme ST3GAL2 contributes to the biosynthesis of sialylated glycoconjugates which are important in cellular communication and stability. It plays a role in producing sialyl Lewis X (sLeX) a ligand involved in cell adhesion. ST3GAL2 operates as part of the Golgi glycosylation machinery and influences the functional properties of cell surface molecules. Its activity impacts processes such as immune response and signaling pathways where the proper display of sialylated structures is required for interacting with selectins.
- Pathways
ST3GAL2 plays a vital role in the glycosylation and glycan biosynthesis pathways. It impacts the O-glycan biosynthesis pathway where it contributes to the capping of glycan chains with sialic acid. This sialylation process affects the recognition and binding activities of selectins a family of cell adhesion proteins. In particular ST3GAL2 interacts with other enzymes like ST3GAL1 and ST6GAL1 both of which participate in creating complex glycan structures.
- Associated diseases and disorders
ST3GAL2 associates with cancer and neurological disorders. Altered sialylation patterns driven by overexpression or underexpression of ST3GAL2 can influence tumor progression and metastasis. In cancer changes in glycan structures affect interactions with the immune system and modulate cell migration. Additionally ST3GAL2 connects to disorders involving the immune system as modifications in glycan structures can impact the function of immune-related proteins like selectins influencing inflammatory response and immune escape mechanisms in tumor environments.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ST3GAL2 antibody (ab254726)
Paraffin-embedded human hippocampus tissue stained for ST3GAL2 using ab254726 at 1/50 dilution in immunohistochemical analysis.
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