Anti-ST3GAL5 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ST3GAL5 also known as GM3 synthase or SAT-I is an enzyme that catalyzes the transfer of sialic acid to lactosylceramide forming ganglioside GM3. This enzyme belongs to the glycosyltransferase family and has a molecular mass of approximately 43 kDa. It is expressed in a variety of tissues with significant presence in the brain where it plays role in neural cell interactions.

Biological function summary

The enzyme ST3GAL5 influences cell communication proliferation and differentiation through the synthesis of gangliosides. It does not function as part of a larger complex but acts independently to produce ganglioside GM3. GM3 is significant in membrane microdomains known as lipid rafts which are involved in cellular signaling. Through influencing these lipid rafts ST3GAL5 indirectly affects numerous cellular processes including signaling events in nerve cells.

Pathways

ST3GAL5 is integral in the lipid metabolism pathway particularly in ganglioside biosynthesis. It interacts with other enzymes involved in the production of more complex gangliosides such as ST8SIA1 which further converts GM3 to GD3. Additionally it plays role in the insulin signaling pathway where GM3 participates in modulating insulin receptor function. ST3GAL5's enzymatic product GM3 can affect receptor activity by insertion into lipid rafts influencing insulin signaling efficiency.

Associated diseases and disorders

ST3GAL5 links to disorders like hereditary spastic paraplegia and epilepsy. Mutations in the ST3GAL5 gene can lead to disruptions in ganglioside metabolism resulting in impaired neural function. Moreover its dysfunctional biosynthesis affects the vascular endothelial growth factor (VEGF) signaling pathway contributing to irregularities in angiogenesis that may relate to diseases like cancer. The intricate balance maintained by ST3GAL5 and associated proteins in these pathways highlights its importance in maintaining normal cellular function.