Rabbit Polyclonal ST5 antibody. Suitable for WB and reacts with Rat, Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DENND2B aa 550-600.
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Publications
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- Frontiers in oncology 11:6215002021Suppression of Tumorigenicity 5 Ameliorates Tumor Characteristics of Invasive Breast Cancer Cells ERK/JNK Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJianghong Cheng,Mingli Li,Chi-Meng Tzeng,Xingchun Gou,Shuai ChenPubMed 34395234
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human DENND2B aa 550-600. The exact immunogen used to generate this antibody is proprietary information. Database link P78524
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Tested |
| Rat | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 0.10000-0.50000 µg/mL | Notes - |
Species Mouse | Dilution info 0.10000-0.50000 µg/mL | Notes - |
Species Human | Dilution info 0.10000-0.50000 µg/mL | Notes - |
Target data
Function
Isoform 1. May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). Isoform 2. Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Isoform 3. May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable).
Alternative names
HTS1, ST5, DENND2B, DENN domain-containing protein 2B, HeLa tumor suppression 1, Suppression of tumorigenicity 5 protein
Recommended products
Rabbit Polyclonal ST5 antibody. Suitable for WB and reacts with Rat, Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DENND2B aa 550-600.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human DENND2B aa 550-600. The exact immunogen used to generate this antibody is proprietary information. Database link P78524
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ST5 also known as Suppression of Tumorigenicity 5 is a protein with a molecular weight of approximately 126 kDa. It is expressed in various tissues including the brain and reproductive organs. This protein is part of a larger family characterized by motifs involved in protein-protein interactions. Research indicates that ST5 may play a role in cellular processes like growth and differentiation.
- Biological function summary
The cellular activity of ST5 involves signal transduction and modulation of cellular structures. It interacts with multiple proteins forming complexes that contribute to its regulatory roles. This protein has functions that affect cell motility and structural organization within cells. Scientists believe ST5 could influence cellular adhesion and the maintenance of tissue architecture.
- Pathways
Cell motility and structure regulation feature ST5 prominently in the MAPK signaling pathway. ST5 interacts with proteins such as the ERK and MEK which are key components of this pathway. ST5's involvement in this signaling may affect cellular responses to external stimuli and enable changes that influence cell movement and stability.
- Associated diseases and disorders
Aberrations in the activity of ST5 can contribute to cancer and neurological disorders. Specifically altered expression or function of ST5 has associations with tumor progression and invasion in certain cancers. In the context of neurological conditions disruptions in ST5 regulation might link to proteins involved in neurodegenerative diseases affecting neural structural integrity and cellular communication.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-ST5 antibody (ab187759)
All lanes: Western blot - Anti-ST5 antibody (ab187759) at 0.5 µg/mL
Lane 1: Rat Testis Tissue Lysate at 40 µg
Lane 2: A431 Whole Cell Lysate at 40 µg
Lane 3: HeLa Whole Cell Lysate at 40 µg
Lane 4: COLO320 Whole Cell Lysate at 40 µg
Lane 5: NIH Whole Cell Lysate at 40 µg
Predicted band size: 126 kDa
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