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AB187759

Anti-ST5 antibody

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(2 Publications)

Rabbit Polyclonal ST5 antibody. Suitable for WB and reacts with Rat, Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DENND2B aa 550-600.

View Alternative Names

HTS1, ST5, DENND2B, DENN domain-containing protein 2B, HeLa tumor suppression 1, Suppression of tumorigenicity 5 protein

1 Images
Western blot - Anti-ST5 antibody (AB187759)
  • WB

Supplier Data

Western blot - Anti-ST5 antibody (AB187759)

All lanes:

Western blot - Anti-ST5 antibody (ab187759) at 0.5 µg/mL

Lane 1:

Rat Testis Tissue Lysate at 40 µg

Lane 2:

A431 Whole Cell Lysate at 40 µg

Lane 3:

HeLa Whole Cell Lysate at 40 µg

Lane 4:

COLO320 Whole Cell Lysate at 40 µg

Lane 5:

NIH Whole Cell Lysate at 40 µg

Predicted band size: 126 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human DENND2B aa 550-600. The exact immunogen used to generate this antibody is proprietary information.

P78524

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ST5 also known as Suppression of Tumorigenicity 5 is a protein with a molecular weight of approximately 126 kDa. It is expressed in various tissues including the brain and reproductive organs. This protein is part of a larger family characterized by motifs involved in protein-protein interactions. Research indicates that ST5 may play a role in cellular processes like growth and differentiation.
Biological function summary

The cellular activity of ST5 involves signal transduction and modulation of cellular structures. It interacts with multiple proteins forming complexes that contribute to its regulatory roles. This protein has functions that affect cell motility and structural organization within cells. Scientists believe ST5 could influence cellular adhesion and the maintenance of tissue architecture.

Pathways

Cell motility and structure regulation feature ST5 prominently in the MAPK signaling pathway. ST5 interacts with proteins such as the ERK and MEK which are key components of this pathway. ST5's involvement in this signaling may affect cellular responses to external stimuli and enable changes that influence cell movement and stability.

Aberrations in the activity of ST5 can contribute to cancer and neurological disorders. Specifically altered expression or function of ST5 has associations with tumor progression and invasion in certain cancers. In the context of neurological conditions disruptions in ST5 regulation might link to proteins involved in neurodegenerative diseases affecting neural structural integrity and cellular communication.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Isoform 1. May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed : 29030480).. Isoform 2. Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.. Isoform 3. May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable).
See full target information DENND2B
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

The journal of headache and pain 23:152 PubMed36456902

2022

Expression of vasopressin and its receptors in migraine-related regions in CNS and the trigeminal system: influence of sex.

Applications

Unspecified application

Species

Unspecified reactive species

Aida Maddahi,Lars Edvinsson,Karin Warfvinge

Frontiers in oncology 11:621500 PubMed34395234

2021

Suppression of Tumorigenicity 5 Ameliorates Tumor Characteristics of Invasive Breast Cancer Cells ERK/JNK Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jianghong Cheng,Mingli Li,Chi-Meng Tzeng,Xingchun Gou,Shuai Chen
View all publications
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