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AB214920

Anti-ST6GAL2 antibody

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Sheep Polyclonal ST6GAL2 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ST6GAL2 aa 200-550.

View Alternative Names

KIAA1877, SIAT2, ST6GAL2, ST6Gal II, Sialyltransferase 2, ST6GalII, hST6Gal II

1 Images
Western blot - Anti-ST6GAL2 antibody (AB214920)
  • WB

Supplier Data

Western blot - Anti-ST6GAL2 antibody (AB214920)

All lanes:

Western blot - Anti-ST6GAL2 antibody (ab214920) at 1/1000 dilution

All lanes:

Human brain tissue lysate

Predicted band size: 60 kDa

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Key facts

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ST6GAL2 aa 200-550. The exact immunogen used to generate this antibody is proprietary information.

Q96JF0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with PBS at 500µg/mL
Purification technique
Affinity purification Immunogen
Purification notes
The IgG fraction of immunized serum was purified by antigen affinity chromatography and lyophilized from a 0.2 µm filtered solution in phosphate-buffered saline (PBS).
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ST6GAL2 also known as ST6 beta-galactoside alpha-26-sialyltransferase 2 is an enzyme that catalyzes the transfer of sialic acid to galactose-containing substrates. This glycosylation process impacts the structure and function of glycoproteins and glycolipids. The mass of ST6GAL2 is approximately 56 kDa. It is mainly expressed in the brain and liver and also found in lower levels in some other tissues suggesting roles in specific physiological functions.
Biological function summary

The enzyme plays an integral role in the sialylation of glycan structures influencing cellular interactions and signaling pathways. It does not generally function as a component of a larger complex but works independently in modifying glycoproteins which are important for cell surface interactions neural development and immune response. The sialylation impacts the recognition and binding abilities of glycosylated molecules affecting both intra- and inter-cellular communication.

Pathways

This enzyme is vital in the sialylation branch of the glycosylation pathway which is important in the synthesis of complex carbohydrates on cell surfaces. This pathway intersects with insulin signaling where glycoproteins engage in regulatory feedback mechanisms. ST6GAL2 also relates to the immune response pathways where its activity modifies the surface antigens therefore impacting interactions with immune receptors.

Aberrant ST6GAL2 expression and activity link to neurodegenerative diseases like Alzheimer's and metabolic disorders such as diabetes. In Alzheimer's disease changes in glycoprotein sialylation can affect amyloid precursor protein processes whereas in diabetes altered sialylation impairs insulin receptor function. ST6GAL2 interacts with related proteins such as amyloid-beta precursor protein in neurodegeneration and insulin in diabetes influencing pathological progressions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.
See full target information ST6GAL2
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Product promise

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