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AB127016

Anti-ST6GALNAC4 antibody

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(3 Publications)

Rabbit Polyclonal ST6GALNAC4 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ST6GALNAC4 aa 50-300.

View Alternative Names

SIAT3C, SIAT7D, ST6GALNAC4, ST6GalNAc IV, Sialyltransferase 3C, Sialyltransferase 7D, ST6GalNAcIV, SIAT3-C, SIAT7-D

1 Images
Western blot - Anti-ST6GALNAC4 antibody (AB127016)
  • WB

Unknown

Western blot - Anti-ST6GALNAC4 antibody (AB127016)

10% SDS PAGE

All lanes:

Western blot - Anti-ST6GALNAC4 antibody (ab127016) at 1/1000 dilution

All lanes:

HCT116 whole cell lysate at 30 µg

Predicted band size: 34 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ST6GALNAC4 aa 50-300. The exact immunogen used to generate this antibody is proprietary information.

Q9H4F1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ST6GALNAC4 also known as ST6 N-acetylgalactosaminide alpha-26-sialyltransferase 4 is an enzyme involved in the biochemical process of transferring sialic acid to specific glycoproteins and glycolipids. This protein has a molecular mass of around 59 kDa. It operates within the Golgi apparatus where it contributes to the modification of glycoconjugates. Expression of ST6GALNAC4 occurs in various tissues but it shows higher activity in the brain and liver which suggests its importance in the function of these organs.
Biological function summary

ST6GALNAC4 serves in the synthesis and modification of sialylated glycoproteins. It plays an integral role in producing sialyl-Tn (sTn) antigen a sialylated glycan structure. The enzyme does not function as part of a large protein complex but interacts with other glycosyltransferases to achieve specific glycan modifications. These interactions are important for cellular communication adhesion and immune responses.

Pathways

ST6GALNAC4 is essential in the sialylation pathway influencing glycosylation patterns that affect cell surface properties. Glycosylation changes can modulate interactions with other proteins such as selectins and integrins. ST6GALNAC4 activity has implications for pathways related to cellular movement and interaction partially through the modulation of proteins like MUC1 a mucin involved in forming protective mucous barriers and signaling.

ST6GALNAC4 connections appear significant in certain cancers and inflammatory conditions. The overexpression of sTn antigen resulting from ST6GALNAC4 activity is often linked to breast cancer aiding tumor progression and metastasis. Additionally aberrant sialylation by ST6GALNAC4 can affect immune response associating it with inflammatory bowel diseases. The protein's involvement with other enzymes such as ST6GAL1 helps modulate these disease pathways accentuating the role of glycosylation in disease development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. Prefers O-glycans to glycoproteins or glycolipids.
See full target information ST6GALNAC4
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 10:e40405 PubMed39687103

2024

Establishment of prognostic risk model related to disulfidptosis and immune infiltration in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhe Xu,Chong Pang,Xundi Xu

Journal of hepatocellular carcinoma 10:531-551 PubMed37034303

2023

Identification and Experimental Validation of the Prognostic Significance and Immunological Correlation of Glycosylation-Related Signature and ST6GALNAC4 in Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Tianxing Dai,Jing Li,Run-Bin Liang,Haoyuan Yu,Xu Lu,Guoying Wang

International journal of clinical and experimental 12:3357-3366 PubMed31934178

2019

The oncogenic role of TRIP13 in regulating proliferation, invasion, and cell cycle checkpoint in NSCLC cells.

Applications

Unspecified application

Species

Unspecified reactive species

Qiao Zhang,Yan Dong,Shaohuan Hao,Ying Tong,Qin Luo,Patiguli Aerxiding
View all publications
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