Anti-STAM antibody [RP23040090]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

STAM or Signal Transducing Adaptor Molecule is a protein involved in intracellular signaling pathways. It is also known by the alternate name STAM-1 and has a mass of approximately 55 kDa. STAM is expressed in various tissues with a significant presence in the immune and hematopoietic systems. Its mechanical role involves interacting with different cellular components to facilitate signal transduction. The protein mainly localizes to the cytoplasm and occasionally associates with membrane-bound organelles.

Biological function summary

STAM engages in processes that are essential for signal transduction and endosomal sorting. It works as part of a larger protein complex known as the ESCRT-0 complex which is important for regulating endocytosis and sorting of ubiquitinated membrane proteins. This complex includes other proteins such as Hrs and plays a role in the degradation of signaling receptors assisting in modulating cell signaling and maintaining cellular equilibrium.

Pathways

STAM is implicated in the endocytic and ubiquitin-proteasome systems. It interacts significantly with the endocytosis pathway participating in the sorting of endocytic vesicles. In this context STAM's function involves cooperation with proteins like Hrs in the ESCRT machinery which manages membrane receptor recycling and degradation. By controlling these pathways it modulates signal transduction and influences cell fate decisions.

Associated diseases and disorders

STAM's dysfunction is linked to certain conditions including cancer and neurodegenerative diseases. In cancer aberrant STAM function can result in uncontrolled cellular proliferation as seen with its association with proteins such as c-MET a receptor tyrosine kinase. In neurodegenerative diseases malfunction of STAM can disrupt cellular homeostasis and protein degradation pathways contributing to neuronal cell death. Understanding STAM's interactions and pathways can provide insights into potential therapeutic targets for these diseases.