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AB239518

Anti-Stanniocalcin 1/STC antibody [C5]

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(3 Publications)

Mouse Monoclonal Stanniocalcin 1/STC antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STC1 aa 1 to C-terminus.

View Alternative Names

STC, STC1, Stanniocalcin-1, STC-1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stanniocalcin 1/STC antibody [C5] (AB239518)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stanniocalcin 1/STC antibody [C5] (AB239518)

Formalin-fixed, paraffin-embedded human kidney tissue stained for Stanniocalcin 1/STC with ab239518 at 10 μg/ml in immunohistochemical analysis. DAB staining. HRP-Goat Anti-Mouse IgG secondary antibody was used at 2 μg/ml.

Western blot - Anti-Stanniocalcin 1/STC antibody [C5] (AB239518)
  • WB

Supplier Data

Western blot - Anti-Stanniocalcin 1/STC antibody [C5] (AB239518)

All lanes:

Western blot - Anti-Stanniocalcin 1/STC antibody [C5] (ab239518) at 5 µg/mL

All lanes:

Recombinant human Stanniocalcin 1/STC protein

Predicted band size: 28 kDa

false

Western blot - Anti-Stanniocalcin 1/STC antibody [C5] (AB239518)
  • WB

Supplier Data

Western blot - Anti-Stanniocalcin 1/STC antibody [C5] (AB239518)

All lanes:

Western blot - Anti-Stanniocalcin 1/STC antibody [C5] (ab239518) at 3 µg/mL

All lanes:

Pig testis tissue lysate

Secondary

All lanes:

HRP-Goat Anti-Mouse IgG at 0.2 µg/mL

Predicted band size: 28 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

C5

Isotype

IgG2b

Light chain type

kappa

Carrier free

No

Reacts with

Human, Pig

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human STC1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P52823

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Alternative Products

Primary Antibodies

AB229477

Anti-Stanniocalcin 1/STC antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stanniocalcin 1/STC antibody (AB229477)

  • 0
  • 0
Primary Antibodies

AB124891

Anti-Stanniocalcin 1/STC antibody [EPR6055]

RabMAb|Recombinant

Western blot - Anti-Stanniocalcin 1/STC antibody [EPR6055] (AB124891)

  • 0
  • 0

Complementary Products

Assay Kits

AB213829

Human Stanniocalcin 1 / STC ELISA Kit (STC1)

Sandwich ELISA - Human Stanniocalcin 1 / STC ELISA Kit (STC1) (AB213829)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88
Primary Antibodies

AB28364

Anti-CD31 antibody

BOND RX™ Validated|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody (AB28364)

  • 4
  • 160
Assay Kits

AB213829

Human Stanniocalcin 1 / STC ELISA Kit (STC1)

Sandwich ELISA - Human Stanniocalcin 1 / STC ELISA Kit (STC1) (AB213829)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-30 µg/mL", "IHCP-species-notes": "<p></p>" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
Purified from TCS.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Stanniocalcin 1 (STC1) is a glycoprotein hormone with a mass of about 56 kDa. Alternate names for this protein include STC and STC-1. It is expressed in various tissues such as the kidney brain and ovary. STC1 plays a significant mechanical role in the regulation of calcium and phosphate transport across cell membranes. It interacts with certain receptors on cell surfaces to modulate ion exchange contributing to the maintenance of mineral homeostasis.
Biological function summary

Stanniocalcin 1 regulates calcium and phosphate balance and performs roles in cellular metabolism and antioxidant defense. It acts independently not as part of a complex but sometimes affects cascades leading to oxidative stress responses. STC1 adjusts energy metabolism by managing reactive oxygen species thereby enhancing cell survival under stress conditions. Its signaling impacts energy balance and adaptive responses in metabolically active tissues.

Pathways

Despite its independent operation Stanniocalcin 1 is integrated into oxidative stress and inflammatory pathways. It is involved in the Akt/PKB signaling pathway which influences cell survival and stress response. STC1 intersects with other proteins like PTH (parathyroid hormone) within the calcium metabolism pathways affecting bone and renal function. Through these pathways it facilitates cellular adaptation to metabolic demands.

Researchers link Stanniocalcin 1 to osteoporosis and cancer. Its role in calcium homeostasis makes it relevant in osteoporosis where bone density and strength are compromised. In the context of cancer STC1's influence on cell survival and stress responses may contribute to tumorigenesis although its function can be protective or detrimental depending on the cellular environment. The interaction of STC1 with proteins like PTH highlights its involvement in bone-related pathologies and potential roles in cancer progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
See full target information STC1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in neurology 16:1642150 PubMed40860972

2025

Electroacupuncture enhances mesenchymal stem cell therapy via improved perfusion and inflammation modulation in peripheral nerve injury: an IVIM-MRI study in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Junfeng Li,Qiuyi Chen,Jintong Pan,Fanqi Meng,Wensheng Huang,Yingying Liang,Xuewen Yu,Ruirui Qi,Peiyin Luo,Haodong Qin,Yueyao Chen,Xiaofeng Lin

Journal of biochemical and molecular toxicology 36:e23025 PubMed35603999

2022

NF-κB-upregulated miR-155-5p promotes hepatocyte mitochondrial dysfunction to accelerate the development of nonalcoholic fatty liver disease through downregulation of STC1.

Applications

Unspecified application

Species

Unspecified reactive species

Miao Shen,Hanghai Pan,Jinjing Ke,Fei Zhao

Frontiers in cell and developmental biology 9:731086 PubMed34722511

2021

Molecular and Clinical Significance of Stanniocalcin-1 Expression in Breast Cancer Through Promotion of Homologous Recombination-Mediated DNA Damage Repair.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Hou,Jigan Cheng,ZeHua Dai,Na Wei,Huan Chen,Shu Wang,Min Dai,Leilei Li,Hua Wang,Qing Ni
View all publications
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Product promise

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