AB262857

Anti-Stanniocalcin 2/STC-2 antibody

Name: Anti-Stanniocalcin 2/STC-2 antibody (ab262857) | Abcam
Brand: Abcam Limited
SKU: AB262857
Price: 655 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal Stanniocalcin 2/STC-2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Stanniocalcin-2 aa 200 to C-terminus.

View Alternative Names

Stanniocalcin-2, STC-2, Stanniocalcin-related protein, STC-related protein, STCRP, STC2

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stanniocalcin 2/STC-2 antibody (AB262857)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stanniocalcin 2/STC-2 antibody (AB262857)

Paraffin-embedded Human prostate tissue stained for Stanniocalcin 2/STC-2 using ab262857 at 1/500 dilution in immunohistochemical analysis.

Unknown

Western blot - Anti-Stanniocalcin 2/STC-2 antibody (AB262857)

All lanes:

Western blot - Anti-Stanniocalcin 2/STC-2 antibody (ab262857) at 0.4 µg/mL

All lanes:

TD47D cell lysate

Predicted band size: 33 kDa

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Immunocytochemistry/ Immunofluorescence - Anti-Stanniocalcin 2/STC-2 antibody (AB262857)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Stanniocalcin 2/STC-2 antibody (AB262857)

PFA-fixed, Triton X-100 permeabilized human U-251MG cells stained for Stanniocalcin 2/STC-2 (green) using ab262857 at 4 µg/ml in ICC/IF.

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Western blot - Anti-Stanniocalcin 2/STC-2 antibody (AB262857)

All lanes:

Western blot - Anti-Stanniocalcin 2/STC-2 antibody (ab262857) at 0.4 µg/mL

Lane 1:

Vector only transfected control

Lane 2:

Stanniocalcin 2/STC-2 overexpression HEK-293T lysate

Predicted band size: 33 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Stanniocalcin-2 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O76061

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.4 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "Fixation/Permeabilization: PFA/Triton X-100" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Stanniocalcin 2 (STC-2) is a glycoprotein hormone known for regulating calcium and phosphate homeostasis. It has other names like STC-1-related protein and STC2. The protein has a mass of approximately 33 kDa. STC-2 expresses in various tissues with high levels in the liver kidney and thyroid gland. Its expression suggests an important role in maintaining mineral balance in these tissues.

Biological function summary

STC-2 influences metabolic and inflammatory processes by modulating cellular responses to calcium and phosphate. It operates partly by binding to receptors on cell surfaces impacting cell proliferation and survival. While not part of a known complex STC-2 interacts with signaling molecules involved in bone metabolism and endocrine function serving as a modulator of mineralized tissue homeostasis.

Pathways

In mineral homeostasis STC-2 interacts within pathways involving calcium and phosphate regulation. Its interactions include overlap with the PTH (parathyroid hormone) and vitamin D pathways each critical for calcium and bone metabolism. STC-2 shows connections with proteins like FGF23 (fibroblast growth factor 23) that also participate in these regulatory networks impacting how cells manage mineral concentrations.

Research indicates STC-2's involvement in conditions such as chronic kidney disease and some cancers. Its expression levels correlate with abnormal mineral metabolism in kidney disease where it may interact with proteins like Klotho a known regulator of phosphate transport. In oncology overexpression of STC-2 associates with cancer progression potentially linking to altered signaling pathways in tumor cells.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

See full target information Stanniocalcin-2

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death discovery 8:308 PubMed35790735

2022

Stanniocalcin 2 drives malignant transformation of human glioblastoma cells by targeting SNAI2 and Matrix Metalloproteinases.

Applications

Unspecified application

Species

Unspecified reactive species

Eun-Jin Yun,Donghwi Kim,Jer-Tsong Hsieh,Seung Tae Baek

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Stanniocalcin 2/STC-2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stanniocalcin 2/STC-2 antibody (AB262857)

Western blot - Anti-Stanniocalcin 2/STC-2 antibody (AB262857)

Immunocytochemistry/ Immunofluorescence - Anti-Stanniocalcin 2/STC-2 antibody (AB262857)

Western blot - Anti-Stanniocalcin 2/STC-2 antibody (AB262857)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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