Rabbit Polyclonal ETXA antibody. Suitable for ELISA, WB and reacts with Staphylococcus aureus samples. Cited in 2 publications.
pH: 7.4
Constituents: PBS
| ELISA | WB | |
|---|---|---|
| Staphylococcus aureus | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Staphylococcus aureus | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Staphylococcus aureus | Dilution info Use at an assay dependent concentration. | Notes - |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules (PubMed:12467569, PubMed:2658055). In turn, waves of cellular activation, cytokine production, and migration into the lung tissue and airways occur via alphabeta T-cells (PubMed:23321986). Causes also the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death (Probable).
Enterotoxin type A, SEA, entA
Rabbit Polyclonal ETXA antibody. Suitable for ELISA, WB and reacts with Staphylococcus aureus samples. Cited in 2 publications.
pH: 7.4
Constituents: PBS
Ab15897 gives absorbance readings (410 nm) of less than 0.100 for 10 ng/ml preparations of staphylococcal enterotoxins B through E, ET, TSST, and alpha hemolysin.
Cross reacts with Staphylococcus Enterotoxin E
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Staphylococcus Enterotoxin A (SEA) also known simply as Enterotoxin A is one of the key virulence factors produced by the bacterium Staphylococcus aureus. This protein is classified as an enterotoxin and has a molecular mass of approximately 27 kDa. SEA is endogenously expressed by Staphylococcus aureus and it is known to exert its effects in the human gastrointestinal tract by binding to major histocompatibility complex (MHC) class II molecules thereby activating T-cells.
The function of SEA involves triggering a strong immune response through its role as a superantigen. Enterotoxins such as SEA can bypass the conventional antigen presentation pathway leading to massive cytokine release. This protein can provoke a large-scale activation of T-cells not through specific antigen binding but rather through cross-linking of MHC class II molecules and T-cell receptors. SEA does not typically form complexes with other proteins as its main mechanism of action relies on interaction with cell surface receptors.
SEA integrates into the immune response pathway by inducing excessive cytokine production contributing to inflammation. It plays a notable role in the cytokine signaling pathway causing unregulated production of inflammatory cytokines. This interferes with normal immune system function leading to toxic shock syndrome in severe cases. SEA also has a connection with other enterotoxins produced by Staphylococcus aureus such as Enterotoxin B through its role in stimulating immune responses.
SEA is associated with food poisoning and toxic shock syndrome. Food poisoning arises from the ingestion of food contaminated with SEA leading to nausea vomiting and diarrhea. Toxic shock syndrome occurs when SEA enters the bloodstream causing systemic inflammation and acute symptoms. SEA has an indirect relationship with other staphylococcal toxins as they share similar pathways in disease progression including Enterotoxin B which also contributes to toxic shock syndrome.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com