AB252733

Anti-Staphylococcus Enterotoxin H antibody

Be the first to review this product! Submit a review

(0 Publication)

Rabbit Polyclonal Staphylococcus Enterotoxin H antibody. Suitable for ELISA and reacts with Staphylococcus aureus samples.

View Alternative Names

seh, entH, Enterotoxin type H, SEH

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Staphylococcus aureus

Applications

ELISA

applications

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Staphylococcus aureus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" } } }

style

left-column

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Constituents: 0.9% Sodium chloride, 0.16% Sodium phosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Staphylococcus Enterotoxin H also known as SEH is a potent superantigen produced by the bacterium Staphylococcus aureus. With a mass of around 26 kDa this enterotoxin is secreted by the bacteria and can be found in human tissues and environment contaminated by this pathogen. Mechanically SEH functions by binding to major histocompatibility complex (MHC) class II molecules on antigen-presenting cells and T-cell receptors on T cells forming a cross-link that leads to excessive activation of the immune response.

Biological function summary

Staphylococcus enterotoxin H plays a significant role in immune system dysregulation by inducing an overproduction of cytokines. It does not form part of a larger complex but operates as a single entity capable of bridging MHC class II and T-cell receptors. This bridging causes non-specific polyclonal T-cell activation which subsequently leads to a large cytokine release causing systemic inflammatory responses.

Pathways

Superantigens like Staphylococcus enterotoxin H engage prominently in the immunological synapse pathway. This interaction involves important signaling pathways such as the MAPK and NF-kB pathways which carry signals resulting from superantigen activation to execute inflammatory responses. Other proteins that come into play through these pathways include IL-2 and TNF-alpha which are key mediators in the signaling cascade triggered by SEH.

Staphylococcus enterotoxin H is linked to conditions such as toxic shock syndrome and food poisoning. This association arises due to the uncontrolled cytokine storm that SEH provokes resulting in severe systemic symptoms. SEH relates to other staphylococcal enterotoxins like SEB—both participate in similar pathological processes and contribute to the severity and incidence of related clinical symptoms in infected individuals.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules via their alpha domain, in particular TRAV27 (PubMed : 12682246, PubMed : 17709482, PubMed : 21081917). In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of pro-inflammatory cytokines (PubMed : 10586065, PubMed : 12682246). Causes also the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death (PubMed : 16213675).

See full target information entH

style

left-column

style

left-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

style

left-column

style

right-column

style

bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com