AB203193

Anti-StAR antibody

Name: Anti-StAR antibody (ab203193) | Abcam
Brand: Abcam Limited
SKU: AB203193
Price: 435 USD
Availability: InStock
Rating: 5 (2 reviews)

(2 Reviews)

(11 Publications)

Rabbit Polyclonal STAR antibody. Suitable for IHC-P, WB and reacts with Mouse, Rat, Human samples. Cited in 11 publications. Immunogen corresponding to Synthetic Peptide within Human STAR aa 100-200 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

STARD1, STAR, StAR, START domain-containing protein 1, StARD1

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody (AB203193)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody (AB203193)

Immunohistochemical analysis of formalin-fixed paraffin-embedded rat kidney tissue, labeling StAR using ab203193 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody (AB203193)

Immunohistochemical analysis of formalin-fixed paraffin-embedded mouse embryo tissue, labeling StAR using ab203193 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human STAR aa 100-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P49675

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "Use at 1/50 - 1/200 with fluorescent detection methods.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "Use at 1/50 - 1/200 with fluorescent detection methods.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Steroidogenic Acute Regulatory protein (StAR) also known as STARD1 plays an important role in steroid hormone synthesis. It facilitates the transport of cholesterol from the outer to the inner mitochondrial membrane essential for steroid biosynthesis. StAR has a molecular mass of approximately 30 kDa. Expression of StAR occurs predominantly in steroidogenic tissues like adrenal glands ovaries and testes. The protein's efficient functioning is necessary for the maintenance of proper steroid hormone levels in the body.

Biological function summary

The transport activity of StAR is important for the production of steroid hormones which are pivotal in numerous physiological functions. StAR does not function alone; it forms a part of a larger complex of proteins involved in mitochondrial cholesterol transfer. By enabling the conversion of cholesterol to pregnenolone a precursor to various steroid hormones StAR directly affects processes such as metabolism immune function and sexual differentiation. Abnormalities in these processes can result from disruptions in StAR's activity.

Pathways

The involvement of StAR in cholesterol transport places it in the important steroidogenic pathway. This pathway includes interactions with other pivotal proteins such as cytochrome P450scc (CYP11A1) which further converts cholesterol into pregnenolone. Another important pathway where StAR participates is the adrenal biosynthesis pathway linking it to the production of glucocorticoids and mineralocorticoids. Disruption in these pathways due to StAR deficiency or malfunction can lead to severe biological implications.

StAR is closely associated with conditions like lipoid congenital adrenal hyperplasia (LCAH) and Addison's disease. Mutations or deficiencies in StAR can interrupt steroid hormone production which is essential for managing these conditions. Additionally proteins like CYP11A1 may show functional impairment in the presence of StAR mutations exacerbating these disorders. A deeper understanding of StAR's role in these conditions can support the development of targeted therapeutic strategies.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

See full target information STAR

style

left-column

Publications (11)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed40076863

2025

Astaxanthin Alleviates Oxidative Stress in Mouse Preantral Follicles and Enhances Follicular Development Through the AMPK Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jiaqi He,Yue Zhong,Yaqiu Li,Sitong Liu,Xiaoyan Pan

Reproduction (Cambridge, England) 168: PubMed39190000

2024

Characterization of urethra closure in female neonatal mice at histological and molecular levels.

Applications

Unspecified application

Species

Unspecified reactive species

Abigail S Kitakule,Ciro M Amato,Humphrey Hung-Chang Yao

The world journal of men's health 41:446-459 PubMed36649918

2023

Korean Ginseng Berry Extract Enhances the Male Steroidogenesis Enzymes and .

Applications

Unspecified application

Species

Unspecified reactive species

Hyun Joo Chung,Sang Jun Lee,Ara Jang,Chae Eun Lee,Da Won Lee,Soon Chul Myung,Jin Wook Kim

Histochemistry and cell biology 156:561-581 PubMed34515835

2021

Impaired macrophages and failure of steroidogenesis and spermatogenesis in rat testes with cytokines deficiency induced by diacerein.

Applications

Unspecified application

Species

Unspecified reactive species

Salmo Azambuja de Oliveira,Paulo Sérgio Cerri,Estela Sasso-Cerri

Scientific reports 10:1281 PubMed31992765

2020

Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells.

Applications

Unspecified application

Species

Unspecified reactive species

Qiuming Qi,Xishi Liu,Qi Zhang,Sun-Wei Guo

International journal of endocrinology 2019:6785289 PubMed31263496

2019

Effects of Exposure to Bisphenol A during Pregnancy on the Pup Testis Function.

Applications

Unspecified application

Species

Unspecified reactive species

Qingtao Yang,Xuxia Sui,Junjun Cao,Caixia Liu,Shukai Zheng,Mian Bao,Yuanni Huang,Kusheng Wu

The journal of pain 20:577-591 PubMed30500366

2018

Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Xuhui Chen,Zuofan Li,Bo Zhang,Rong Hu,Jiayan Li,Miaomiao Feng,Wenlong Yao,Chuanhan Zhang,Li Wan,Yue Zhang

Animal cells and systems 22:407-414 PubMed30533263

2018

Steroidogenic effects of extract on the levels of steroidogenic enzymes in mouse Leydig cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hyun Joo Chung,Yoohun Noh,Min Su Kim,Ara Jang,Chae Eun Lee,Soon Chul Myung

Life sciences 197:1-9 PubMed29482802

2018

Effects of electroacupuncture on luteal regression and steroidogenesis in ovarian hyperstimulation syndrome model rat.

Applications

Species

Unspecified reactive species

Xuan Huang,Li Chen,You-Bing Xia,Min Xie,Qin Sun,Bing Yao

Molecular medicine reports 16:491-498 PubMed28560422

2017

Effects of maternal acrolein exposure during pregnancy on testicular testosterone production in fetal rats.

Applications

Unspecified application

Species

Unspecified reactive species

Yuzhuo Yang,Zhe Zhang,Hongliang Zhang,Kai Hong,Wenhao Tang,Lianming Zhao,Haocheng Lin,Defeng Liu,Jiaming Mao,Han Wu,Hui Jiang

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-StAR antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody (AB203193)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody (AB203193)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (11)

Alternative Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise