AB233427

Anti-StAR antibody

Name: Anti-StAR antibody (ab233427) | Abcam
Brand: Abcam Limited
SKU: AB233427

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(7 Publications)

Rabbit Polyclonal STAR antibody. Suitable for WB, IHC-P and reacts with Rat, Pig, Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human STAR.

View Alternative Names

STARD1, STAR, StAR, START domain-containing protein 1, StARD1

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody (AB233427)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody (AB233427)

Formalin-fixed, paraffin-embedded human kidney tissue stained for StAR using ab233427 at 20μg/mL in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-StAR antibody (AB233427)

All lanes:

Western blot - Anti-StAR antibody (ab233427) at 2 µg/mL

All lanes:

Rat adrenal gland lysate

Predicted band size: 32 kDa

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Supplier Data

Western blot - Anti-StAR antibody (AB233427)

All lanes:

Western blot - Anti-StAR antibody (ab233427) at 2 µg/mL

All lanes:

Pig adrenal gland tissue lysate

Predicted band size: 32 kDa

false

Supplier Data

Western blot - Anti-StAR antibody (AB233427)

All lanes:

Western blot - Anti-StAR antibody (ab233427) at 2 µg/mL

All lanes:

Recombinant human StAR protein

Predicted band size: 32 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human, Pig

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human STAR.

P49675

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Steroidogenic Acute Regulatory protein (StAR) also known as STARD1 plays an important role in steroid hormone synthesis. It facilitates the transport of cholesterol from the outer to the inner mitochondrial membrane essential for steroid biosynthesis. StAR has a molecular mass of approximately 30 kDa. Expression of StAR occurs predominantly in steroidogenic tissues like adrenal glands ovaries and testes. The protein's efficient functioning is necessary for the maintenance of proper steroid hormone levels in the body.

Biological function summary

The transport activity of StAR is important for the production of steroid hormones which are pivotal in numerous physiological functions. StAR does not function alone; it forms a part of a larger complex of proteins involved in mitochondrial cholesterol transfer. By enabling the conversion of cholesterol to pregnenolone a precursor to various steroid hormones StAR directly affects processes such as metabolism immune function and sexual differentiation. Abnormalities in these processes can result from disruptions in StAR's activity.

Pathways

The involvement of StAR in cholesterol transport places it in the important steroidogenic pathway. This pathway includes interactions with other pivotal proteins such as cytochrome P450scc (CYP11A1) which further converts cholesterol into pregnenolone. Another important pathway where StAR participates is the adrenal biosynthesis pathway linking it to the production of glucocorticoids and mineralocorticoids. Disruption in these pathways due to StAR deficiency or malfunction can lead to severe biological implications.

StAR is closely associated with conditions like lipoid congenital adrenal hyperplasia (LCAH) and Addison's disease. Mutations or deficiencies in StAR can interrupt steroid hormone production which is essential for managing these conditions. Additionally proteins like CYP11A1 may show functional impairment in the presence of StAR mutations exacerbating these disorders. A deeper understanding of StAR's role in these conditions can support the development of targeted therapeutic strategies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

See full target information STAR

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

The Tohoku journal of experimental medicine 264:9-19 PubMed38839357

2024

Shenqi Qiangjing Granules Ameliorate Asthenozoospermia in Mice by Regulating Ferroptosis through the METTL3/GPX4 Signaling Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Qiuyu Lu,Jiabao Ma,Luying Wei,Jing Fu,Xiaoxia Li,Kedao Lai,Xin Li,Bingyu Xia,Bin Bin,Aicun Tang

Biology of reproduction 110:154-168 PubMed37815939

2023

Phoenixin-14 as a novel direct regulator of porcine luteal cell functions†.

Applications

Unspecified application

Species

Unspecified reactive species

Ewa Mlyczyńska,Patrycja Kurowska,Dominika Wachowska,Małgorzata Grzesiak,Joelle Dupont,Agnieszka Rak

International journal of molecular sciences 24: PubMed36614200

2023

Expression and Function of StAR in Cancerous and Non-Cancerous Human and Mouse Breast Tissues: New Insights into Diagnosis and Treatment of Hormone-Sensitive Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Pulak R Manna,Sabarish Ramachandran,Jangampalli Adi Pradeepkiran,Deborah Molehin,Isabel Castro-Piedras,Kevin Pruitt,Vadivel Ganapathy,P Hemachandra Reddy

Antioxidants (Basel, Switzerland) 11: PubMed36290786

2022

Prevention of Testicular Damage by Indole Derivative MMINA via Upregulated StAR and CatSper Channels with Coincident Suppression of Oxidative Stress and Inflammation: In Silico and In Vivo Validation.

Applications

Unspecified application

Species

Unspecified reactive species

Tayyaba Afsar,Suhail Razak,Janeen H Trembley,Khushbukhat Khan,Maria Shabbir,Ali Almajwal,Nawaf W Alruwaili,Muhammad Umar Ijaz

The Journal of endocrinology 247:283-294 PubMed33108345

2020

The role of vaspin in porcine corpus luteum.

Applications

Unspecified application

Species

Unspecified reactive species

Patrycja Kurowska,Ewa Mlyczyńska,Monika Dawid,Małgorzata Grzesiak,Joelle Dupont,Agnieszka Rak

Biology of reproduction 102:1290-1305 PubMed32149334

2020

Role of vaspin in porcine ovary: effect on signaling pathways and steroid synthesis via GRP78 receptor and protein kinase A†.

Applications

Unspecified application

Species

Unspecified reactive species

Patrycja Kurowska,Ewa Mlyczyńska,Monika Dawid,Joelle Dupont,Agnieszka Rak

EBioMedicine 50:166-177 PubMed31761616

2019

Sprouty4 correlates with favorable prognosis in perihilar cholangiocarcinoma by blocking the FGFR-ERK signaling pathway and arresting the cell cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Qiu,Tianli Chen,Rongqi Sun,Zengli Liu,Xiaoming Zhang,Zhipeng Li,Yunfei Xu,Zongli Zhang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-StAR antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody (AB233427)

Western blot - Anti-StAR antibody (AB233427)

Western blot - Anti-StAR antibody (AB233427)

Western blot - Anti-StAR antibody (AB233427)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (7)

Product promise