Mouse Monoclonal STAR antibody. Carrier free. Suitable for IHC-P, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human STAR aa 1-150.
Images
![Protein Array - Anti-StAR antibody [STAR/2140] - BSA and Azide free (AB237907), expandable thumbnail](https://content.abcam.com/products/images/star-antibody-star-2140-bsa-and-azide-free-ab237907--protein-array-img141151.jpg/_jcr_content/renditions/webp-475.webp "Protein Array - Anti-StAR antibody [STAR/2140] - BSA and Azide free (AB237907)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2140] - BSA and Azide free (AB237907), expandable thumbnail](https://content.abcam.com/products/images/star-antibody-star-2140-bsa-and-azide-free-ab237907--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img104397.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2140] - BSA and Azide free (AB237907)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2140] - BSA and Azide free (AB237907), expandable thumbnail](https://content.abcam.com/products/images/star-antibody-star-2140-bsa-and-azide-free-ab237907--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img132230.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2140] - BSA and Azide free (AB237907)")
Key facts
- Isotype
IgG2b
- Host species
Mouse
- Storage buffer
pH: 7.2 - 7.4
Constituents: PBS- Form
Liquid
- Clonality
Monoclonal
Immunogen
- Recombinant Fragment Protein within Human STAR aa 1-150. The exact immunogen used to generate this antibody is proprietary information. Database link P49675
Reactivity data
Select an application| IHC-P | Protein Array | |
|---|---|---|
| Human | Tested | Expected |
| Recombinant full length protein - Human | Not recommended | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1-2 µg/mL | Notes Incubate with primary ab for 30 minutes at RT Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant full length protein - Human | Dilution info - | Notes - |
Protein Array
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant full length protein - Human | Dilution info - | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Associated Products
Select an associated product type
7 products for Alternative Product
1 products for Alternative Version
Target data
Function
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
Alternative names
StAR, START domain-containing protein 1, StARD1, STAR, STARD1
Recommended products
Mouse Monoclonal STAR antibody. Carrier free. Suitable for IHC-P, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human STAR aa 1-150.
Alternative names
StAR, START domain-containing protein 1, StARD1, STAR, STARD1
Key facts
- Isotype
IgG2b
- Host species
Mouse
- Storage buffer
pH: 7.2 - 7.4
Constituents: PBS- Form
Liquid
- Clonality
Monoclonal
- Immunogen
- Recombinant Fragment Protein within Human STAR aa 1-150. The exact immunogen used to generate this antibody is proprietary information. Database link P49675
- Carrier free
Yes
- Clone number
STAR/2140
- Purification technique
Affinity purification Protein A/G
- Light chain type
kappa
- Concentration
- Purification notes
Ab purified from Bioreactor Concentrate by Protein A/G.
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Steroidogenic Acute Regulatory protein (StAR) also known as STARD1 plays an important role in steroid hormone synthesis. It facilitates the transport of cholesterol from the outer to the inner mitochondrial membrane essential for steroid biosynthesis. StAR has a molecular mass of approximately 30 kDa. Expression of StAR occurs predominantly in steroidogenic tissues like adrenal glands ovaries and testes. The protein's efficient functioning is necessary for the maintenance of proper steroid hormone levels in the body.
- Biological function summary
The transport activity of StAR is important for the production of steroid hormones which are pivotal in numerous physiological functions. StAR does not function alone; it forms a part of a larger complex of proteins involved in mitochondrial cholesterol transfer. By enabling the conversion of cholesterol to pregnenolone a precursor to various steroid hormones StAR directly affects processes such as metabolism immune function and sexual differentiation. Abnormalities in these processes can result from disruptions in StAR's activity.
- Pathways
The involvement of StAR in cholesterol transport places it in the important steroidogenic pathway. This pathway includes interactions with other pivotal proteins such as cytochrome P450scc (CYP11A1) which further converts cholesterol into pregnenolone. Another important pathway where StAR participates is the adrenal biosynthesis pathway linking it to the production of glucocorticoids and mineralocorticoids. Disruption in these pathways due to StAR deficiency or malfunction can lead to severe biological implications.
- Associated diseases and disorders
StAR is closely associated with conditions like lipoid congenital adrenal hyperplasia (LCAH) and Addison's disease. Mutations or deficiencies in StAR can interrupt steroid hormone production which is essential for managing these conditions. Additionally proteins like CYP11A1 may show functional impairment in the presence of StAR mutations exacerbating these disorders. A deeper understanding of StAR's role in these conditions can support the development of targeted therapeutic strategies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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Full details and terms and conditions can be found here:
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3 product images
![Protein Array - Anti-StAR antibody [STAR/2140] - BSA and Azide free (ab237907), expandable thumbnail](https://content.abcam.com/products/images/star-antibody-star-2140-bsa-and-azide-free-ab237907--protein-array-img141151.jpg "Protein Array - Anti-StAR antibody [STAR/2140] - BSA and Azide free (ab237907)")
Protein Array - Anti-StAR antibody [STAR/2140] - BSA and Azide free (ab237907)
This data was produced with Anti-StAR antibody [STAR/2140] ab238056, the same antibody in a different formulation with BSA and Azide.
Anti-StAR antibody [STAR/2140] ab238056 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2140] - BSA and Azide free (ab237907), expandable thumbnail](https://content.abcam.com/products/images/star-antibody-star-2140-bsa-and-azide-free-ab237907--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img104397.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2140] - BSA and Azide free (ab237907)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2140] - BSA and Azide free (ab237907)
Formalin-fixed, paraffin-embedded human testicular carcinoma tissue stained for StAR using ab237907 at 2 μg/mL in immunohistochemical analysis.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2140] - BSA and Azide free (ab237907), expandable thumbnail](https://content.abcam.com/products/images/star-antibody-star-2140-bsa-and-azide-free-ab237907--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img132230.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2140] - BSA and Azide free (ab237907)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2140] - BSA and Azide free (ab237907)
Formalin-fixed, paraffin-embedded human adrenal gland tissue stained for StAR using ab237907 at 2 μg/mL in immunohistochemical analysis.
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