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AB238057

Anti-StAR antibody [STAR/2154]

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(1 Publication)

Mouse Monoclonal STAR antibody. Suitable for IHC-P, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STAR aa 1-150.

View Alternative Names

STARD1, STAR, StAR, START domain-containing protein 1, StARD1

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2154] (AB238057)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2154] (AB238057)

Formalin-fixed, paraffin-embedded human adrenal gland tissue stained for StAR using ab238057 at 2 μg/mL in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2154] (AB238057)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2154] (AB238057)

Formalin-fixed, paraffin-embedded human testicular carcinoma tissue stained for StAR using ab238057 at 2 μg/mL in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2154] (AB238057)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StAR antibody [STAR/2154] (AB238057)

Formalin-fixed, paraffin-embedded human testicular carcinoma tissue stained for StAR using ab238057 at 2 μg/mL in immunohistochemical analysis.

Protein Array - Anti-StAR antibody [STAR/2154] (AB238057)
  • Protein Array

Unknown

Protein Array - Anti-StAR antibody [STAR/2154] (AB238057)

ab238057 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

STAR/2154

Isotype

IgG1

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

IHC-P, Protein Array

applications

Immunogen

Recombinant Fragment Protein within Human STAR aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

P49675

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ProteinArray" : {"fullname" : "Protein Array", "shortname":"Protein Array"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p>Incubate with primary ab for 30 minutes at RT</p>", "ProteinArray-species-checked": "guaranteed", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "" }, "Recombinant full length protein - Human": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ProteinArray-species-checked": "testedAndGuaranteed", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
Ab purified from Bioreactor Concentrate by Protein A/G.
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Steroidogenic Acute Regulatory protein (StAR) also known as STARD1 plays an important role in steroid hormone synthesis. It facilitates the transport of cholesterol from the outer to the inner mitochondrial membrane essential for steroid biosynthesis. StAR has a molecular mass of approximately 30 kDa. Expression of StAR occurs predominantly in steroidogenic tissues like adrenal glands ovaries and testes. The protein's efficient functioning is necessary for the maintenance of proper steroid hormone levels in the body.
Biological function summary

The transport activity of StAR is important for the production of steroid hormones which are pivotal in numerous physiological functions. StAR does not function alone; it forms a part of a larger complex of proteins involved in mitochondrial cholesterol transfer. By enabling the conversion of cholesterol to pregnenolone a precursor to various steroid hormones StAR directly affects processes such as metabolism immune function and sexual differentiation. Abnormalities in these processes can result from disruptions in StAR's activity.

Pathways

The involvement of StAR in cholesterol transport places it in the important steroidogenic pathway. This pathway includes interactions with other pivotal proteins such as cytochrome P450scc (CYP11A1) which further converts cholesterol into pregnenolone. Another important pathway where StAR participates is the adrenal biosynthesis pathway linking it to the production of glucocorticoids and mineralocorticoids. Disruption in these pathways due to StAR deficiency or malfunction can lead to severe biological implications.

StAR is closely associated with conditions like lipoid congenital adrenal hyperplasia (LCAH) and Addison's disease. Mutations or deficiencies in StAR can interrupt steroid hormone production which is essential for managing these conditions. Additionally proteins like CYP11A1 may show functional impairment in the presence of StAR mutations exacerbating these disorders. A deeper understanding of StAR's role in these conditions can support the development of targeted therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
See full target information STAR
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Redox biology 70:103039 PubMed38241838

2024

SPTBN2 suppresses ferroptosis in NSCLC cells by facilitating SLC7A11 membrane trafficking and localization.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Deng,Xu Lin,Jiajia Qin,Qi Li,Yingqiong Zhang,Qingyi Zhang,Cong Ji,Shuying Shen,Yangling Li,Bo Zhang,Nengming Lin
View all publications
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