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AB126489

Anti-StARD13 antibody

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(5 Publications)

Rabbit Polyclonal StARD13 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STARD13.

View Alternative Names

DLC2, GT650, STARD13, StAR-related lipid transfer protein 13, 46H23.2, Deleted in liver cancer 2 protein, Rho GTPase-activating protein, START domain-containing protein 13, DLC-2, StARD13

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StARD13 antibody (AB126489)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-StARD13 antibody (AB126489)

ab126489 at 1/200 dilution staining StARD13 in paraffin-embedded Human pancreas tissue by Immunohistochemistry.

Western blot - Anti-StARD13 antibody (AB126489)
  • WB

Unknown

Western blot - Anti-StARD13 antibody (AB126489)

All lanes:

Western blot - Anti-StARD13 antibody (ab126489) at 1/250 dilution

Lane 1:

RT4 cell lysate

Lane 2:

U251 MG cell lysate

Lane 3:

Human plasma lysate

Lane 4:

Human liver tissue lysate

Lane 5:

Human tonsil tissue lysate

Predicted band size: 125 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human STARD13. The exact immunogen used to generate this antibody is proprietary information.

Q9Y3M8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/250 - 1/500", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

StARD13 also known as DLC2 is a member of the START domain-containing proteins characterized by its RhoGAP activity which regulates Rho family GTPases by accelerating the hydrolysis of GTP to GDP. It has a molecular mass of approximately 112 kDa. This protein exhibits expression in various tissues including the liver where it significantly plays a role in cellular processes. StARD13 features a START domain responsible for lipid-binding anchoring it in cellular membranes and providing substrate specificity.
Biological function summary

StARD13 influences cellular organization by impacting actin cytoskeleton dynamics and cell migration. It interacts predominantly within protein complexes involving Rho GTPases such as RhoA and RhoC. The protein shapes cell shape and motility by acting as a tumor suppressor mainly through modulating actin cytoskeleton rearrangement. Additionally StARD13 maintains cellular homeostasis and suppresses cell proliferation in a normal tissue environment.

Pathways

StARD13 holds a notable place within signaling pathways like the Rho signaling pathway and the Hippo pathway. These pathways are essential for regulating cell proliferation motility and survival critical for maintaining cellular physiology and architecture. The StARD13 protein acts alongside other pathway-related proteins such as YAP in the Hippo pathway and the ROCK kinase in the Rho signaling pathway influencing various intracellular signaling cascades.

StARD13 shows notable associations with cancer and fibrosis. Research indicates its tumor suppressor role especially in the context of hepatocellular carcinoma where downregulation correlates with increased tumor progression and invasiveness. The relation with fibrosis particularly liver fibrosis highlights its involvement in tissue remodeling and wound healing processes. Additionally through disease mechanisms StARD13 connects to the p53 protein in cancer pathways enhancing apoptosis and suppressing abnormal cellular growth.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.
See full target information STARD13
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Computational and mathematical methods in medicine 2021:7074343 PubMed34335864

2021

miR-182-5p Serves as an Oncogene in Lung Adenocarcinoma through Binding to STARD13.

Applications

Unspecified application

Species

Unspecified reactive species

Xuhui Wu,Wei Wang,Gongzhi Wu,CongXiong Peng,Jichun Liu

BMC pulmonary medicine 21:242 PubMed34281560

2021

LINC01089 suppresses lung adenocarcinoma cell proliferation and migration via miR-301b-3p/STARD13 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Ye Qian,Yan Zhang,Haoming Ji,Yucheng Shen,Liangfeng Zheng,Shouliang Cheng,Xiaomin Lu

Molecular medicine reports 19:4881-4889 PubMed31059015

2019

High expression of DLC family proteins predicts better prognosis and inhibits tumor progression in NSCLC.

Applications

Unspecified application

Species

Unspecified reactive species

Li Sun,Jing Sun,Jun-Ding Song

Oncology letters 17:2107-2116 PubMed30719106

2019

DLC2 operates as a tumor suppressor gene in breast cancer via the RhoGTPase pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zheng Yang,Hanrui Chen,Man Shu,Yunjian Zhang,Ling Xue,Yuan Lin

OncoTargets and therapy 11:5371-5381 PubMed30214243

2018

STARD13 is positively correlated with good prognosis and enhances 5-FU sensitivity via suppressing cancer stemness in hepatocellular carcinoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Fei Gao,Xiaolin Yu,Rongqin Meng,Jisheng Wang,Lin Jia
View all publications
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