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AB121592

Anti-STARD3NL antibody

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(2 Publications)

Rabbit Polyclonal STARD3NL antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STARD3NL aa 1-100.

View Alternative Names

MENTHO, UNQ855/PRO1864, STARD3NL, STARD3 N-terminal-like protein, MLN64 N-terminal domain homolog

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STARD3NL antibody (AB121592)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STARD3NL antibody (AB121592)

ab121592, at a 1/75 dilution, staining STARD3NL in glandular cells of paraffin-embedded Human duodenum tissue by Immunohistochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-STARD3NL antibody (AB121592)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-STARD3NL antibody (AB121592)

Immunofluorescent staining of Human cell line U-2 OS shows positivity in vesicles. Recommended concentration of ab121592 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Western blot - Anti-STARD3NL antibody (AB121592)
  • WB

Unknown

Western blot - Anti-STARD3NL antibody (AB121592)

Lane 1 : Marker [kDa] 250; 130; 95; 72; 55; 36; 28; 17; 10
Lane 2 : Negative control (vector only transfected HEK293T lysate)
Lane 3 : Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells. Lane 1 : Marker [kDa] 250; 130; 95; 72; 55; 36; 28; 17; 10
Lane 2 : Negative control (vector only transfected HEK293T lysate)
Lane 3 : Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells.

All lanes:

Western blot - Anti-STARD3NL antibody (ab121592)

Predicted band size: 27 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human STARD3NL aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

O95772

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STARD3NL also known as StAR-related lipid transfer domain containing 3 N-terminal like is a protein that functions mechanically to transfer lipids between membranes. This protein has an estimated mass of approximately 47 kDa. It is expressed in multiple tissues with high levels found in the liver and kidneys. STARD3NL performs its functions within the cell by interacting with membranes affecting lipid metabolism.
Biological function summary

STARD3NL plays a role in regulating lipid transport and homeostasis. It is involved in cellular processes that ensure the proper distribution of lipids which is essential for membrane integrity and energy storage. STARD3NL may function as part of a larger protein complex that facilitates these processes. Its exact role within the complex could be linked to the modulation of cholesterol distribution.

Pathways

STARD3NL is involved in the dynamic lipid metabolism and transport pathways. It participates in the intracellular lipid transport pathway important for ensuring lipid availability. STARD3NL works alongside proteins like STARD3 which also belong to the StAR-related lipid transfer (START) domain-containing family. This cooperation influences the function and pathways related to cholesterol homeostasis.

STARD3NL has links to disorders related to cholesterol metabolism and lipid accumulation. Its dysregulation may contribute to conditions like Niemann-Pick disease where cholesterol transport becomes impaired. In this context STARD3NL interacts with proteins like NPC1 and NPC2 which are important for the regulation of intracellular cholesterol trafficking and are implicated in lipid storage diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes : localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed : 24105263).
See full target information STARD3NL
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 11:1127 PubMed32111841

2020

Selective EMC subunits act as molecular tethers of intracellular organelles exploited during viral entry.

Applications

Unspecified application

Species

Unspecified reactive species

Parikshit Bagchi,Mauricio Torres,Ling Qi,Billy Tsai

Molecular carcinogenesis 56:1837-1850 PubMed28218476

2017

Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation.

Applications

Unspecified application

Species

Unspecified reactive species

Martina Benešová,Kateřina Trejbalová,Dana Kučerová,Zdenka Vernerová,Tomáš Hron,Arpád Szabó,Rachel Amouroux,Petr Klézl,Petra Hajkova,Jiří Hejnar
View all publications
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