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AB126832

Anti-STAT5 antibody

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(4 Publications)

Rabbit Polyclonal STAT5a antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human STAT5A aa 650-700.

View Alternative Names

STAT5, STAT5A, Signal transducer and activator of transcription 5A

2 Images
Western blot - Anti-STAT5 antibody (AB126832)
  • WB

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Western blot - Anti-STAT5 antibody (AB126832)

All lanes:

Western blot - Anti-STAT5 antibody (ab126832) at 1/1000 dilution

Lane 1:

K562 cell lysate at 3 µg

Lane 2:

K562 cell lysate at 10 µg

Lane 3:

K562 cell lysate at 30 µg

Predicted band size: 91 kDa

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Western blot - Anti-STAT5 antibody (AB126832)
  • WB

Unknown

Western blot - Anti-STAT5 antibody (AB126832)

All lanes:

Western blot - Anti-STAT5 antibody (ab126832) at 1/1000 dilution

Lane 1:

Human recombinant STAT1 beta at 0.005 µg

Lane 2:

Human recombinant STAT2 at 0.005 µg

Lane 3:

Human recombinant STAT3 at 0.005 µg

Lane 4:

Human recombinant STAT4 at 0.005 µg

Lane 5:

Human recombinant STAT5 at 0.005 µg

Lane 6:

Human recombinant STAT6 at 0.005 µg

Predicted band size: 91 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human STAT5A aa 650-700. The exact immunogen used to generate this antibody is proprietary information.

P42229

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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Product details

For storage at 4°C for several months add 0.1% NaN3.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Signal Transducer and Activator of Transcription 5 commonly known as STAT5 is a member of the STAT protein family. It weighs approximately 94 kDa. STAT5 usually exists in two closely related forms STAT5a and STAT5b with both playing similar roles but having slightly different activity. This protein is widely expressed found in cells like lymphocytes epithelial cells and endothelial cells indicating its importance in various tissues.
Biological function summary

STAT5 acts as a transcription factor that modulates gene expression by binding to specific DNA sequences. It often forms part of a larger complex when activated. This complex relocation to the nucleus triggers transcriptional activities essential for cell growth differentiation and survival. As it interacts with other proteins STAT5 plays an important role in cytokine signaling particularly in response to interleukins and growth hormones.

Pathways

STAT5 is important in the JAK-STAT signaling pathway. This pathway is activated by cytokines and growth factors leading to STAT5 phosphorylation and its subsequent translocation into the nucleus. The interaction with Janus kinases (JAKs) facilitates this process. STAT5 also plays a significant role in the MAPK pathway linking it to various cellular responses and functions.

STAT5 has a strong association with oncological conditions like leukemia and lymphomas. Aberrant activation or dysregulation of STAT5 can lead to uncontrolled cell proliferation and survival contributing to cancer. Furthermore STAT5 is linked with autoimmune diseases with its malfunction affecting immune response and leading to disorders. In these conditions proteins like BCL-XL often interact with STAT5 influencing cell survival pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Carries out a dual function : signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
See full target information STAT5A
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Life science alliance 6: PubMed37085288

2023

inhibited the methylation of to suppress the progression of PC by targeting .

Applications

Unspecified application

Species

Unspecified reactive species

Kaiqiong Wang,Dongwei Gong,Xin Qiao,Jinfang Zheng

Cell transplantation 32:9636897221149444 PubMed36644879

2023

CD27-Expressing Xenoantigen-Expanded Human Regulatory T Cells Are Efficient in Suppressing Xenogeneic Immune Response.

Applications

Unspecified application

Species

Unspecified reactive species

Lu Cao,Xiaoqian Ma,Juan Zhang,Min Yang,Zhenhu He,Cejun Yang,Sang Li,Pengfei Rong,Wei Wang

FASEB bioAdvances 1:353-363 PubMed31844843

2019

Stimulation of Prostate Cells by the Senescence Phenotype of Epithelial and Stromal Cells: Implication for Benign Prostate Hyperplasia.

Applications

Unspecified application

Species

Unspecified reactive species

Shoulei Jiang,Chung Seog Song,Bandana Chatterjee

Journal of immunology research 2018:6985031 PubMed30013992

2018

STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4 T Cells of Patients with Colorectal Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hulin Ma,Weishi Gao,Xiaoxia Sun,Weixing Wang
View all publications
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