JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB254889

Anti-Statherin antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal Statherin antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STATH aa 1-100.
4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Statherin antibody (AB254889)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Statherin antibody (AB254889)

Paraffin-embedded human duodenum tissue shows absence of immunoreactivity for Statherin when incubated with ab254889 at 1/1000 dilution (negative control).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Statherin antibody (AB254889)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Statherin antibody (AB254889)

Paraffin-embedded human salivary gland tissue stained for Statherin using ab254889 at 1/1000 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Statherin antibody (AB254889)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Statherin antibody (AB254889)

Paraffin-embedded human skeletal muscle tissue shows absence of immunoreactivity for Statherin when incubated with ab254889 at 1/1000 dilution (negative control).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Statherin antibody (AB254889)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Statherin antibody (AB254889)

Paraffin-embedded human tonsil tissue shows absence of immunoreactivity for Statherin when incubated with ab254889 at 1/1000 dilution (negative control).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human STATH aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P02808

style
left-column

Complementary Products

Proteins & Peptides

AB276578

Recombinant Human Statherin protein (Fc Chimera)

SDS-PAGE - Recombinant Human Statherin protein (Fc Chimera) (AB276578)

  • 0
  • 0
Primary Antibodies

AB182408

Anti-IGF1 Receptor antibody [EPR19322]

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry - Anti-IGF1 Receptor antibody [EPR19322] (AB182408)

  • 4
  • 2
Primary Antibodies

AB302958

Anti-PI 3 Kinase catalytic subunit gamma/PI3K-gamma antibody [EPR25156-60]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry - Anti-PI 3 Kinase catalytic subunit gamma/PI3K-gamma antibody [EPR25156-60] (AB302958)

  • 0
  • 0
Primary Antibodies

AB212668

Anti-Myogenin antibody [SPM144] - BSA and Azide free

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myogenin antibody [SPM144] - BSA and Azide free (AB212668)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Statherin also known as STA-1 is a small protein with a molecular mass of roughly 5.4 kDa. This protein is found predominantly in human saliva secreted by the salivary glands including the parotid gland. Statherin plays a mechanical role in maintaining the stability of the mineral content in saliva which is important for the prevention of calcium phosphate precipitation. By binding calcium ions Statherin keeps the saliva supersaturated with calcium phosphate which helps prevent unwanted crystallization and maintains the fluidic integrity of the oral cavity.
Biological function summary

Statherin’s function is essential for oral health by playing a significant part in the protection of tooth enamel. It inhibits the spontaneous nucleation of calcium phosphate salts essentially preventing their accumulation on teeth. Its ability to bind to the tooth surface also forms a part of the pellicle a protein film that covers the enamel. Statherin works as a solitary protein in this context and does not usually form complexes with other biomolecules in saliva. However its protective impact on tooth surfaces directly influences oral health by maintaining a balanced enamel surface.

Pathways

Statherin is an important element in the homeostasis of mineralized tissues specifically within the calcium precipitation pathway. It relates to molecules that modulate calcium levels involving interactions with other phospho-proteins such as proline-rich proteins and histatins which also contribute to mineral balance and oral health. These pathways underline the importance of Statherin as a component of the oral environment's stability and function.

Statherin associates closely with dental calculus and caries. Its ability to inhibit calcium phosphate precipitation directly protects against dental plaque formation which if left uncontrolled leads to calculus. Furthermore caries development can relate to inadequate Statherin function highlighting its significance in preventive dentistry. Interactions with proteins like proline-rich proteins in the formation of the enamel pellicle are critical as they can diminish the likelihood of tooth decay by controlling bacterial colonization and mineral deposition.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.
See full target information STATH

Alternative Names

Statherin, STATH
style
left-column

Publications (1)

Recent publications for all applications. Explore the full listand refine your search

Journal of experimental & clinical cancer research : CR 40:134 PubMed33858489

2021

The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Junshuang Zhao,Yang Jiang,Haiying Zhang,Jinpeng Zhou,Lian Chen,Hao Li,Jinkun Xu,Guoqing Zhang,Zhitao Jing
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com