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AB317402

Anti-Staufen/STAU1 antibody [S03-3G2]

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Rabbit Recombinant Monoclonal Staufen/STAU1 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Immunogen corresponding to Synthetic Peptide within Human STAU1.

View Alternative Names

STAU, STAU1, Double-stranded RNA-binding protein Staufen homolog 1, Stau, Double-stranded RNA-binding protein Staufen homolog 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Staufen/STAU1 Antibody [S03-3G2] (AB317402)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Staufen/STAU1 Antibody [S03-3G2] (AB317402)

Immunohistochemistry of Staufen/STAU1 in paraffin-embedded human breast cancer tissue using ab317402 at dilution 1/50.

Western blot - Anti-Staufen/STAU1 Antibody [S03-3G2] (AB317402)
  • WB

Supplier Data

Western blot - Anti-Staufen/STAU1 Antibody [S03-3G2] (AB317402)

All lanes:

Western blot - Anti-Staufen/STAU1 Antibody [S03-3G2] (ab317402) at 1/1000 dilution

Lane 1:

K562 cell lysate

Lane 2:

C6 cell lysate

Lane 3:

NIH/3T3 cell lysate

Predicted band size: 63 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

S03-3G2

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse, Rat

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human STAU1.

O95793

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Product details

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.4 Preservative: 0.01% Sodium azide Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Staufen1 (STAU1) also known as Staufen double-stranded RNA binding protein 1 is an RNA-binding protein that plays a significant role in the regulation of mRNA localization stability and translation. It has a mass of approximately 58 kDa and is expressed in a variety of tissues including the brain testis and heart. STAU1 is known for binding to specific secondary structures in mRNA which influences the post-transcriptional gene regulation processes essential for cell function.
Biological function summary

Staufen1 participates in mRNA transport and localization within cells especially neurons. It forms part of a ribonucleoprotein complex which is involved in the movement of mRNA to distinct subcellular sites facilitating localized protein synthesis. This function is critical for the development and maintenance of cellular structures especially in cells with polarized functions such as neurons where precise protein localization is necessary for synaptic function and plasticity.

Pathways

Staufen1 is essential in processes related to mRNA decay and translation regulation. It is actively involved in the nonsense-mediated mRNA decay pathway ensuring the quality control of mRNA transcripts and preventing the synthesis of defective proteins. Additionally STAU1 interacts with proteins such as UPF1 an important player in this mRNA surveillance mechanism highlighting its role in ensuring accurate protein translation and cellular health.

Abnormalities in STAU1 function have been associated with neurodegenerative diseases and muscular disorders. Its interaction with proteins like SMN responsible for motor neuron maintenance links STAU1 to spinal muscular atrophy. Similarly STAU1's role in the regulation of mRNA at synapses connects it to neuronal disorders including some forms of intellectual disability where local protein synthesis at synapses is disrupted.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.. (Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process.
See full target information STAU1

Additional targets

Stau1,Stau1
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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