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AB140951

Anti-STEAP4 antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal STEAP4 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human STEAP4.

View Alternative Names

STAMP2, TNFAIP9, STEAP4, Metalloreductase STEAP4, Six-transmembrane epithelial antigen of prostate 4, SixTransMembrane protein of prostate 2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STEAP4 antibody - N-terminal (AB140951)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STEAP4 antibody - N-terminal (AB140951)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human pancreas tissue labelling STEAP4 with ab140951 at 2.5 µg/ml after heat-induced antigen retrieval.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human STEAP4. The exact immunogen used to generate this antibody is proprietary information.

Q687X5

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2.5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STEAP4 also known as STEAP4 metalloreductase or TIARP is a membrane-associated protein with a molecular mass of approximately 51 kDa. It mainly functions as a metalloreductase playing a role in the reduction of metal ions particularly iron and copper within cells. You find its expression in various tissues with higher levels in the adipose tissue liver and prostate. This protein is integral to cellular processes that require metal ion homeostasis influencing several pathways through its enzymatic activity on metal reduction.
Biological function summary

The function of STEAP4 extends beyond mere metal ion reduction. It contributes to cellular metabolism and inflammatory response regulation. Researchers have noted its involvement in the modulation of reactive oxygen species (ROS) which are important for detoxification and signaling. This protein does not function in isolation but may work in concert with other proteins in complexes related to the cell membrane and energy metabolism.

Pathways

STEAP4 participates in critical metabolic and inflammatory pathways. In particular it plays a role in the JNK and NF-kB signaling pathways which impact cellular stress responses and inflammation. Interactions with additional regulatory proteins such as TNF-alpha and IL-6 further integrate STEAP4 into these pathways linking its functions with larger cellular processes that respond to external stimuli and stress factors.

STEAP4 has important connections to metabolic and inflammatory conditions. Research shows its involvement in obesity-related inflammation and insulin resistance linking it with metabolic syndrome conditions. You also find associations between STEAP4 expression and type 2 diabetes as its dysfunction may impact glucose and lipid metabolism. This protein's interactions with TNF-alpha and IL-6 also suggest a strong link to chronic inflammatory states which can exacerbate metabolic disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed : 30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed : 18381574, PubMed : 18430367). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed : 19660107). Inhibits anchorage-independent cell proliferation (PubMed : 19787193).
See full target information STEAP4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of Cancer 11:4250-4260 PubMed32368308

2020

IL-2 enhanced MHC class I expression in papillary thyroid cancer with Hashimoto's thyroiditis overcomes immune escape .

Applications

Unspecified application

Species

Unspecified reactive species

Jia-Qian Hu,Bo-Wen Lei,Duo Wen,Ben Ma,Ting-Ting Zhang,Zhong-Wu Lu,Wen-Jun Wei,Yu-Long Wang,Yu Wang,Duan-Shu Li,Qing-Hai Ji,Tian Liao
View all publications
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