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AB223033

Anti-STIM2 antibody

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(1 Publication)

Rabbit Polyclonal STIM2 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STIM2 aa 450-700.

View Alternative Names

KIAA1482, STIM2, Stromal interaction molecule 2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STIM2 antibody (AB223033)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STIM2 antibody (AB223033)

Paraffin-embedded human brain tissue stained for STIM2 using ab223033 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-STIM2 antibody (AB223033)
  • WB

Supplier Data

Western blot - Anti-STIM2 antibody (AB223033)

All lanes:

Western blot - Anti-STIM2 antibody (ab223033) at 1/500 dilution

Lane 1:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate

Lane 2:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate

Lane 3:

Mouse heart tissue lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG at 1/50000 dilution

Predicted band size: 84 kDa

Observed band size: 69 kDa,84 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human STIM2 aa 450-700. The exact immunogen used to generate this antibody is proprietary information.

Q9P246

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Complementary Products

Primary Antibodies

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Primary Antibodies

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Primary Antibodies

AB254260

Anti-Orai3 antibody [EPR22575-17]

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  • 0
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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STIM2 also known as Stromal Interaction Molecule 2 is a protein involved in calcium signaling with a mass of approximately 82 kDa. It is expressed in various tissues including the brain where it functions to regulate calcium entry into cells. STIM2 acts as a sensor that detects decreases in intracellular calcium levels and helps mediate the opening of calcium channels in the plasma membrane.
Biological function summary

The STIM2 protein facilitates calcium homeostasis by working in cooperation with other proteins to form complexes. It plays an essential role in cellular processes by maintaining basal calcium levels. In neuronal cells STIM2 helps regulate synaptic activity and plasticity impacting learning and memory functions. The protein's ability to form complexes and modulate calcium stores is critical for effective cellular signaling.

Pathways

STIM2 is a fundamental component of the store-operated calcium entry (SOCE) pathway which maintains cellular calcium levels. It functions alongside its homolog STIM1 to activate calcium release-activated calcium channels such as ORAI1 facilitating calcium influx into the cell. This regulation is important for the immune responses and muscle function where precise calcium signaling is necessary for optimal cellular performance.

STIM2 has been implicated in neurological disorders such as Alzheimer's disease where altered calcium signaling can contribute to disease progression. STIM2 dysregulation may affect synaptic stability and memory formation leading to cognitive impairment. Additionally the protein associates with disorders involving immune system dysfunction where abnormal SOCE activity plays a role. Its interaction with STIM1 and ORAI1 in these conditions underlines the importance of balanced calcium homeostasis for proper cellular function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.
See full target information STIM2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Stem cells international 2022:9455152 PubMed36061148

2022

miR-3960 from Mesenchymal Stem Cell-Derived Extracellular Vesicles Inactivates SDC1/Wnt/-Catenin Axis to Relieve Chondrocyte Injury in Osteoarthritis by Targeting PHLDA2.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Ye,Zhanhu Mi,Daihao Wei,Pengcheng Gao,Mei Ma,Haibo Yang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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