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AB181258

Anti-STIM2 antibody [EPR12879] - C-terminal

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(1 Publication)

Rabbit Recombinant Monoclonal STIM2 antibody. C-terminal. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

KIAA1482, STIM2, Stromal interaction molecule 2

1 Images
Western blot - Anti-STIM2 antibody [EPR12879] - C-terminal (AB181258)
  • WB

Supplier Data

Western blot - Anti-STIM2 antibody [EPR12879] - C-terminal (AB181258)

All lanes:

Western blot - Anti-STIM2 antibody [EPR12879] - C-terminal (ab181258) at 1/10000 dilution

Lane 1:

A673 cell lysate at 10 µg

Lane 2:

BxPC3 cell lysate at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated) at 1/1000 dilution

Predicted band size: 84 kDa

false

  • Carrier free

    Anti-STIM2 antibody [EPR12879] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR12879

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STIM2 also known as Stromal Interaction Molecule 2 is a protein involved in calcium signaling with a mass of approximately 82 kDa. It is expressed in various tissues including the brain where it functions to regulate calcium entry into cells. STIM2 acts as a sensor that detects decreases in intracellular calcium levels and helps mediate the opening of calcium channels in the plasma membrane.
Biological function summary

The STIM2 protein facilitates calcium homeostasis by working in cooperation with other proteins to form complexes. It plays an essential role in cellular processes by maintaining basal calcium levels. In neuronal cells STIM2 helps regulate synaptic activity and plasticity impacting learning and memory functions. The protein's ability to form complexes and modulate calcium stores is critical for effective cellular signaling.

Pathways

STIM2 is a fundamental component of the store-operated calcium entry (SOCE) pathway which maintains cellular calcium levels. It functions alongside its homolog STIM1 to activate calcium release-activated calcium channels such as ORAI1 facilitating calcium influx into the cell. This regulation is important for the immune responses and muscle function where precise calcium signaling is necessary for optimal cellular performance.

STIM2 has been implicated in neurological disorders such as Alzheimer's disease where altered calcium signaling can contribute to disease progression. STIM2 dysregulation may affect synaptic stability and memory formation leading to cognitive impairment. Additionally the protein associates with disorders involving immune system dysfunction where abnormal SOCE activity plays a role. Its interaction with STIM1 and ORAI1 in these conditions underlines the importance of balanced calcium homeostasis for proper cellular function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.
See full target information STIM2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell calcium 72:70-80 PubMed29748135

2018

Oncogenic KRAS suppresses store-operated Ca entry and I through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines.

Applications

WB

Species

Human

Cristina Pierro,Xuexin Zhang,Cynthia Kankeu,Mohamed Trebak,Martin D Bootman,H Llewelyn Roderick
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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