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Rabbit Polyclonal STIP1/STI1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STIP1 aa 1-300.

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Images

Western blot - Anti-STIP1/STI1 antibody (AB96550), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Anti-STIP1/STI1 antibody (AB96550), expandable thumbnail

Publications

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human STIP1 aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link P31948

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBICC/IF
Human
Tested
Tested
Mouse
Predicted
Predicted
Rat
Predicted
Predicted
Cow
Predicted
Predicted

Tested
Tested

Species
Human
Dilution info
1/500.00000 - 1/3000.00000
Notes

-

Predicted
Predicted

Species
Mouse, Rat, Cow
Dilution info
-
Notes

-

Tested
Tested

Species
Human
Dilution info
1/100.00000 - 1/200.00000
Notes

-

Predicted
Predicted

Species
Mouse, Rat, Cow
Dilution info
-
Notes

-

Associated Products

Select an associated product type

3 products for Alternative Product

Target data

Function

Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).

Alternative names

Recommended products

Rabbit Polyclonal STIP1/STI1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STIP1 aa 1-300.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Recombinant Fragment Protein within Human STIP1 aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link P31948
Purification technique
Affinity purification Immunogen
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

STIP1 also known as STI1 is a stress-induced phosphoprotein that assists in the folding and stabilization of other proteins. The protein has a mass of approximately 63 kDa. It acts as a co-chaperone and interacts with key chaperones like HSP70 and HSP90 facilitating the transfer of client proteins between them. STIP1 is expressed in various tissues with significant presence in the nervous system and reproductive organs. It contributes to the protein homeostasis by modulating chaperone activity and protecting cells during stress conditions like high temperatures or oxidative stress.

Biological function summary

The stress-induced phosphoprotein STIP1 functions within cytoplasm and is pivotal for cellular integrity. It forms a complex with HSP70 and HSP90 that regulates the folding and activation of a range of client proteins including steroid hormone receptors and kinases. This modulation influences protein activity stability and degradation. STIP1 impacts signal transduction pathways cellular growth and stress responses by influencing how effectively client proteins perform their biological roles within cells.

Pathways

The protein STIP1 plays a significant part in the steroid hormone signaling pathway and the protein folding network. It helps facilitate the proper folding and function of steroid hormone receptors through its interaction with major chaperone proteins HSP70 and HSP90. Both these pathways are important for cell survival and proper cell regulation. By helping with the maturation and activation of client proteins STIP1 ensures that cellular responses to various internal and external signals proceed efficiently.

Associated diseases and disorders

The involvement of STIP1 emerges most clearly in neurodegenerative conditions like Alzheimer's disease and cancer. In Alzheimer's disease STIP1 interacts with prion proteins which influence amyloid-beta aggregation and may impact disease progression. In cancer the protein assists in stabilizing client proteins essential for tumor progression such as steroid hormone receptors and protein kinases. Disruption in STIP1 function can lead to impaired cellular stress responses and may contribute to disease pathogenesis.

Product promise

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2 product images

  • Western blot - Anti-STIP1/STI1 antibody (ab96550), expandable thumbnail

    Western blot - Anti-STIP1/STI1 antibody (ab96550)

    7.5% SDS PAGE

    All lanes: Western blot - Anti-STIP1/STI1 antibody (ab96550) at 1/5000 dilution

    Lane 1: HepG2 whole cell lysate at 30 µg

    Lane 2: MOLT4 whole cell lysate at 30 µg

    Predicted band size: 63 kDa

  • Immunocytochemistry/ Immunofluorescence - Anti-STIP1/STI1 antibody (ab96550), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-STIP1/STI1 antibody (ab96550)

    ab96550, at 1/200 dilution, staining STIP1/STI1 in paraformaldehyde-fixed HeLa cells by Immunofluoresence. Lower image is merged with DNA probe.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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