AB8418

Anti-STK17A antibody

Name: Anti-STK17A antibody (ab8418) | Abcam
Brand: Abcam Limited
SKU: AB8418
Price: 535 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal STK17A antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human STK17A aa 1-50.

View Alternative Names

DRAK1, STK17A, Serine/threonine-protein kinase 17A, DAP kinase-related apoptosis-inducing protein kinase 1

3 Images

Supplier Data

Immunocytochemistry - Anti-STK17A antibody (AB8418)

ab8418 at 20μg/ml staining STK17A in MOLT4 cells by ICC/IF.

Unknown

Immunocytochemistry - Anti-STK17A antibody (AB8418)

ab8418 at 2μg/ml staining STK17A in MOLT4 cells by ICC.

Supplier Data

Western blot - Anti-STK17A antibody (AB8418)

All lanes:

Western blot - Anti-STK17A antibody (ab8418) at 1 µg/mL

Lane 1:

MOLT4 whole cell lysate

Lane 2:

A431 whole cell lysate

Predicted band size: 47 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Light chain type

unknown

Carrier free

Reacts with

Human

Applications

ICC, WB

applications

Immunogen

Synthetic Peptide within Human STK17A aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q9UEE5

Specificity

No reactivity to DRAK2, DAP or ZIP kinases.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "2-10 µg/mL", "ICC-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STK17A also known as DRAK1 is a serine/threonine-protein kinase with a mass of approximately 45 kDa. This protein performs a role in cellular signal transduction by phosphorylating serine and threonine residues on target substrates. STK17A is expressed in a variety of human tissues with significant expression in the brain heart and skeletal muscle indicating its widespread regulatory functions.

Biological function summary

The kinase activity of STK17A affects processes like apoptosis and cell migration. It does not form a complex with other proteins but can directly interact with them to exert its influence. Through these interactions STK17A can regulate cell survival and death which are important in development and homeostasis within an organism.

Pathways

STK17A acts in the apoptosis signaling pathway and is known to modulate JNK (c-Jun N-terminal kinase) signaling. In the apoptosis pathway STK17A can modify the response of cells to stress stimuli effectively controlling programmed cell death. It shows functional association with proteins such as caspases which carry out the execution phase of apoptosis thereby linking STK17A to these essential cellular processes.

Dysregulation of STK17A has connections to cancer and neurodegenerative disorders. In cancer altered STK17A expression or activity can contribute to inappropriate cell survival and proliferation making it a relevant marker or target in tumor biology. It associates with proteins like Bcl-2 which are involved in promoting cell survival. In neurodegenerative disorders such as Alzheimer's disease changes in STK17A expression or function might affect neuronal apoptosis contributing to the pathology of these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.

See full target information STK17A

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:4558 PubMed38402348

2024

Biomarker screening using integrated bioinformatics for the development of "normal-impaired glucose intolerance-type 2 diabetes mellitus".

Applications

Unspecified application

Species

Unspecified reactive species

Dongqiang Luo,Xiaolu Gao,Xianqiong Zhu,Jiongbo Xu,Pengfei Gao,Jiayi Zou,Qiaoming Fan,Ying Xu,Tian Liu

European journal of cell biology 97:369-378 PubMed29773344

2018

LncRNA OIP5-AS1 regulates radioresistance by targeting DYRK1A through miR-369-3p in colorectal cancer cells.

Applications

Species

Human

Yanmei Zou,Shuo Yao,Xiuqiong Chen,Dian Liu,Jianhua Wang,Xun Yuan,Jie Rao,Huihua Xiong,Shiying Yu,Xianglin Yuan,Feng Zhu,Guohong Hu,Yihua Wang,Hua Xiong

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-STK17A antibody

Immunocytochemistry - Anti-STK17A antibody (AB8418)

Immunocytochemistry - Anti-STK17A antibody (AB8418)

Western blot - Anti-STK17A antibody (AB8418)

Key facts

Host species

Clonality

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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