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AB97530

Anti-STK17A antibody

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(3 Publications)

Rabbit Polyclonal STK17A antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STK17A aa 1-250.

View Alternative Names

DRAK1, STK17A, Serine/threonine-protein kinase 17A, DAP kinase-related apoptosis-inducing protein kinase 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK17A antibody (AB97530)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK17A antibody (AB97530)

Immunohistochemical analysis of paraffin-embedded SAS xenograft, using ab97530 at 1/500 dilution.

Western blot - Anti-STK17A antibody (AB97530)
  • WB

Unknown

Western blot - Anti-STK17A antibody (AB97530)

7.5% SDS PAGE

All lanes:

Western blot - Anti-STK17A antibody (ab97530) at 1/1000 dilution

All lanes:

Hep G2 whole cell lysate at 30 µg

Predicted band size: 47 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human STK17A aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q9UEE5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STK17A also known as DRAK1 is a serine/threonine-protein kinase with a mass of approximately 45 kDa. This protein performs a role in cellular signal transduction by phosphorylating serine and threonine residues on target substrates. STK17A is expressed in a variety of human tissues with significant expression in the brain heart and skeletal muscle indicating its widespread regulatory functions.
Biological function summary

The kinase activity of STK17A affects processes like apoptosis and cell migration. It does not form a complex with other proteins but can directly interact with them to exert its influence. Through these interactions STK17A can regulate cell survival and death which are important in development and homeostasis within an organism.

Pathways

STK17A acts in the apoptosis signaling pathway and is known to modulate JNK (c-Jun N-terminal kinase) signaling. In the apoptosis pathway STK17A can modify the response of cells to stress stimuli effectively controlling programmed cell death. It shows functional association with proteins such as caspases which carry out the execution phase of apoptosis thereby linking STK17A to these essential cellular processes.

Dysregulation of STK17A has connections to cancer and neurodegenerative disorders. In cancer altered STK17A expression or activity can contribute to inappropriate cell survival and proliferation making it a relevant marker or target in tumor biology. It associates with proteins like Bcl-2 which are involved in promoting cell survival. In neurodegenerative disorders such as Alzheimer's disease changes in STK17A expression or function might affect neuronal apoptosis contributing to the pathology of these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.
See full target information STK17A
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of personalized medicine 11: PubMed34575686

2021

Progression Risk Score Estimation Based on Immunostaining Data in Oral Cancer Using Unsupervised Hierarchical Clustering Analysis: A Retrospective Study in Taiwan.

Applications

Unspecified application

Species

Unspecified reactive species

Hui-Ching Wang,Leong-Perng Chan,Chun-Chieh Wu,Hui-Hua Hsiao,Yi-Chang Liu,Shih-Feng Cho,Jeng-Shiun Du,Ta-Chih Liu,Cheng-Hong Yang,Mei-Ren Pan,Sin-Hua Moi

Oncology reports 45: PubMed33955523

2021

Predictive significance of STK17A in patients with gastric cancer and association with gastric cancer cell proliferation and migration.

Applications

Unspecified application

Species

Unspecified reactive species

Zehua Wang,Chenyi Wang,Bing-Hua Jiang,Litong Shi,Shan Lin,Lei Wang,Ling-Zhi Liu,Jian-Ge Qiu,Yanru Qin,Yongxu Jia

Biochemical and biophysical research communications 441:612-617 PubMed24183720

2013

Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus.

Applications

Unspecified application

Species

Unspecified reactive species

M Guadalupe Martinez,Michele A Bialecki,Sandrine Belouzard,Sandra M Cordo,Nélida A Candurra,Gary R Whittaker
View all publications
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