JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB137813

Anti-STK23 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal STK23 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SRPK3 aa 50-350.

View Alternative Names

MSSK1, STK23, SRPK3, SRSF protein kinase 3, Muscle-specific serine kinase 1, Serine/arginine-rich protein-specific kinase 3, Serine/threonine-protein kinase 23, MSSK-1, SR-protein-specific kinase 3

1 Images
Western blot - Anti-STK23 antibody (AB137813)
  • WB

Unknown

Western blot - Anti-STK23 antibody (AB137813)

7.5% SDS PAGE

All lanes:

Western blot - Anti-STK23 antibody (ab137813) at 1/1000 dilution

All lanes:

293T whole cell lysate at 30 µg

Predicted band size: 62 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human SRPK3 aa 50-350. The exact immunogen used to generate this antibody is proprietary information.

Q9UPE1

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STK23 also known as Serine/Threonine Kinase 23 functions as an active kinase that phosphorylates substrates on serine and threonine residues. This kinase has a molecular mass of approximately 36 kDa. It presents prominently in tissues such as the brain and kidney. STK23's sequence and structure classify it in the kinase family which are key regulators of various cellular processes.
Biological function summary

This kinase plays essential roles in cell cycle regulation and signal transduction. It operates as a single protein and is not part of a larger protein complex. In the context of cellular activities STK23 aids in controlling processes such as mitosis highlighting its significance in maintaining proper cell function.

Pathways

STK23 directly influences the MAPK signaling pathway and is involved in the cell cycle regulation pathway. Through these pathways it interacts with proteins like ERK and other kinases contributing to cell proliferation and differentiation. These interactions place STK23 among the important regulators in cellular growth processes.

Anomalies in STK23 activity connect to cancer and neurological disorders. Its dysregulation has been observed in certain cancers where kinase activity might be upregulated leading to increased cell division. In the context of neurological disorders alterations in STK23 might influence neuron function or viability. In these diseases STK23 shares cofactors or pathways with proteins like CDK for its role in cell cycle dysregulation linking it to pathologies.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity).
See full target information SRPK3
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 12:4852 PubMed34381028

2021

USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaojuan Yang,Guiqin Xu,Boshi Wang,Yun Liu,Li Zhang,Tiantian Jing,Ming Tang,Xiaoli Xu,Kun Jiao,Lvzhu Xiang,Yujie Fu,Daoqiang Tang,Xiaoren Zhang,Weilin Jin,Guanglei Zhuang,Xiaojing Zhao,Yongzhong Liu
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB84801

Recombinant human STK23 protein

Functional Studies - Recombinant human STK23 protein (AB84801)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com